Levonadifloxacin

Levonadifloxacin
Clinical data
Trade namesEmrok
Other names(S)-(-)-Nadifloxacin
Routes of
administration		Parenteral
ATC code
Legal status
Legal status
  • Rx in India
Identifiers
  • (12S)-7-Fluoro-8-(4-hydroxypiperidin-1-yl)-12-methyl-4-oxo-1-azatricyclo[7.3.1.05,13]trideca-2,5,7,9(13)-tetraene-3-carboxylic acid
CAS Number
PubChem CID
UNII
ChEBI
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC19H21FN2O4
Molar mass360.385 g·mol−1
3D model (JSmol)
  • C[C@H]1CCC2=C3N1C=C(C(=O)C3=CC(=C2N4CCC(CC4)O)F)C(=O)O
  • InChI=InChI=1S/C19H21FN2O4/c1-10-2-3-12-16-13(18(24)14(19(25)26)9-22(10)16)8-15(20)17(12)21-6-4-11(23)5-7-21/h8-11,23H,2-7H2,1H3,(H,25,26)/t10-/m0/s1
  • Key:JYJTVFIEFKZWCJ-JTQLQIEISA-N

Levonadifloxacin (trade name Emrok) is an antibiotic drug of the fluoroquinolone class.[1][2] Chemically, it is the (S)-enantiomer of the racemic drug nadifloxacin.

It is approved in India for the treatment of skin and soft tissue infections of Gram-positive bacteria.[3] It is also being studied for potential use against resistant strains of bacteria including Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, and Moraxella catarrhalis.[4]

Levonadifloxacin has poor oral bioavailability. A prodrug of levonadifloxacin with high oral bioavailability, alalevonadifloxacin, has been developed to mitigate this problem.[5]

References

  1. ^ Patel A, Sangle GV, Trivedi J, Shengule SA, Thorve D, Patil M, et al. (April 2020). "Levonadifloxacin, a Novel Benzoquinolizine Fluoroquinolone, Modulates Lipopolysaccharide-Induced Inflammatory Responses in Human Whole-Blood Assay and Murine Acute Lung Injury Model". Antimicrobial Agents and Chemotherapy. 64 (5). doi:10.1128/aac.00084-20. PMC 7179645. PMID 32152077.
  2. ^ Bakthavatchalam YD, Shankar A, Muniyasamy R, Peter JV, Marcus Z, Triplicane Dwarakanathan H, et al. (August 2020). "Levonadifloxacin, a recently approved benzoquinolizine fluoroquinolone, exhibits potent in vitro activity against contemporary Staphylococcus aureus isolates and Bengal Bay clone isolates collected from a large Indian tertiary care hospital". The Journal of Antimicrobial Chemotherapy. 75 (8): 2156–2159. doi:10.1093/jac/dkaa142. PMID 32361727.
  3. ^ "Levonadifloxacin". AdisInsight. Springer Nature Switzerland AG.
  4. ^ Bhagwat SS, Nandanwar M, Kansagara A, Patel A, Takalkar S, Chavan R, et al. (2019). "Levonadifloxacin, a Novel Broad-Spectrum Anti-MRSA Benzoquinolizine Quinolone Agent: Review of Current Evidence". Drug Design, Development and Therapy. 13: 4351–4365. doi:10.2147/DDDT.S229882. PMC 6935279. PMID 31920285.
  5. ^ Bhawsar S, Kale R, Deshpande P, Yeole R, Bhagwat S, Patel M (December 2021). "Design and synthesis of an oral prodrug alalevonadifloxacin for the treatment of MRSA infection". Bioorganic & Medicinal Chemistry Letters. 54: 128432. doi:10.1016/j.bmcl.2021.128432. PMID 34757217.

Read other articles:

The Whale (Tavener)

This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: The Whale Tavener – news · newspapers · books · scholar · JSTOR (January 2017) (Learn how and when to remove this template message) 1970 studio album by John TavenerThe WhaleStudio album by John TavenerReleased25 September 1970 (UK)15 November 197...

 

Winfield, Illinois

Village in Illinois, United StatesWinfield, IllinoisVillageWinfield Town CenterEtymology: Gen. Winfield ScottMotto(s): Growing Smart; In Harmony With NatureLocation of Winfield in DuPage County, IllinoisLocation of Illinois in the United StatesCoordinates: 41°52′39″N 88°9′2″W / 41.87750°N 88.15056°W / 41.87750; -88.15056CountryUnited StatesStateIllinoisCountyDuPageTownshipsMilton, WinfieldIncorporatedApril 18, 1921Government[1] • T...

 

Горностай

У этого термина существуют и другие значения, см. Горностай (значения). Горностай Научная классификация Домен:ЭукариотыЦарство:ЖивотныеПодцарство:ЭуметазоиБез ранга:Двусторонне-симметричныеБез ранга:ВторичноротыеТип:ХордовыеПодтип:ПозвоночныеИнфратип:Челюстнороты...

Бисексуальность

Флаг гордости бисексуалов Бисексуальность      Сексуальные ориентации Бисексуальность Пансексуальность Полисексуальность Моносексуальность Сексуальные идентичности Би-любопытство Гетерогибкость и гомогибкость Сексуальная текучесть Исследования Шк...

 

Rollhockey-Bundesliga 2016-2017

Rollhockey-Bundesliga 2016-2017 Competizione Rollhockey-Bundesliga Sport hockey su pista Edizione 86ª Organizzatore DRVI Date dal 10 settembre 2016al 21 maggio 2017 Luogo  Germania Partecipanti 12 Risultati Vincitore  Iserlohn(9º titolo) Retrocessioni  Bison Calenberg Moskitos Statistiche Incontri disputati 146 Gol segnati 1 602 (10,97 per incontro) Cronologia della competizione 2015-2016 2017-2018 Manuale La Rollhockey-Bundesliga 2016-2017 è stata la...

 

José Justo Corro

Mexican politician In this Spanish name, the first or paternal surname is Corro and the second or maternal family name is Silva. José Justo Corro10th President of MexicoIn office28 February 1836 – 19 April 1837Preceded byMiguel BarragánSucceeded byAnastasio BustamanteMinister of Justice and Ecclesiastical AffairsIn office18 May 1835 – 26 February 1836PresidentMiguel BarragánPreceded byJosé Mariano BlascoSucceeded byJoaquín de Iturbide Personal detailsBor...

Loughborough University

Public university in Loughborough, UK This article contains content that is written like an advertisement. Please help improve it by removing promotional content and inappropriate external links, and by adding encyclopedic content written from a neutral point of view. (April 2024) (Learn how and when to remove this message) Loughborough UniversityCoat of arms of Loughborough UniversityMottoLatin: Veritate, Scientia, LaboreMotto in EnglishBy Truth, Wisdom, and LabourTypePublicEstablished1...

 

Jüdische Gemeinde Bahn

Bahn südlich von Stettin und nordöstlich von Königsberg Nm. auf einer Landkarte von 1905 Die Jüdische Gemeinde Bahn war eine Jüdische Gemeinde, die von der ersten Hälfte des 18. Jahrhunderts bis in die Zeit des Ersten Weltkriegs in der Stadt Bahn in der preußischen Provinz Pommern bestand. Inhaltsverzeichnis 1 Geschichte 2 Gemeindeentwicklung 3 Synagoge 4 Friedhof 5 Literatur 6 Weblinks 7 Einzelnachweise Geschichte Bereits im späten Mittelalter wurden Juden in Bahn genannt. Erst im 17...

 

Frio County, Texas

County in Texas, United States County in TexasFrio CountyCountyThe Frio County Courthouse in PearsallLocation within the U.S. state of TexasTexas's location within the U.S.Coordinates: 28°52′N 99°07′W / 28.86°N 99.11°W / 28.86; -99.11Country United StatesState TexasFounded1871Named forFrio RiverSeatPearsallLargest cityPearsallArea • Total1,134 sq mi (2,940 km2) • Land1,134 sq mi (2,940 km2) �...

Pornographic magazine

Magazines that contain content of an explicitly sexual nature Pornographic magazines on shelves in Japan Pornographic magazines or erotic magazines, sometimes known as adult magazines or sex magazines,[1] are magazines that contain content of an explicitly sexual nature. Publications of this kind may contain images of attractive naked subjects, as is the case in softcore pornography,[1] and, in the usual case of hardcore pornography, depictions of masturbation, oral, manual, v...

 

اصطلاح

تعتمد هذه المقالة اعتماداً كاملاً أو شبه كامل على مصدر وحيد. فضلاً، ساهم في تحسين هذه المقالة بإضافة مصادر إضافية لضمان وجهة النظر المحايدة. الاصطلاح[1] هو اتفاق قوم على تسمية الشيء باسم ما ينقل عن موضوعه الأول، وإخراج اللفظ من معنى لغوي إلى آخر، لمناسبة بينهما. وقيل اتف...

 

2011 FA Community Shield

Football match2011 FA Community ShieldThe match programme cover Manchester City Manchester United 2 3 Date7 August 2011VenueWembley Stadium, LondonMan of the MatchNani (Manchester United)RefereePhil Dowd (Staffordshire)[1]Attendance77,169WeatherRain16 °C (61 °F)[2]← 2010 2012 → The 2011 FA Community Shield (also known as The FA Community Shield sponsored by McDonald's for sponsorship reasons) was the 89th FA Community Shield, an annual football match c...

識字

Part of a series on閱讀 語文 語言 書寫 文字 正寫法 盲文 閱讀的種類 慢速阅读 速讀 默讀 Learning to Read 學習閱讀（英语：Learning to read） 閱讀理解（英语：Reading comprehension） 拼寫 词汇 閱讀困難（英语：Reading disability） 失讀症 為有特殊教學需要而設的閱讀策略（英语：Reading for special needs） 閱讀指引 字母規則（英语：Alphabetic principle） 基础语音教学法 全語言教育 識字 識字 功�...

 

Marocko

Kungariket Marockoالمملكة المغربية al-Mamlaka al-Maghribiyyaⵜⴰⴳⵍⴷⵉⵜ ⵏ ⵍⵎⵖⵔⵉⴱTageldit n l-Maɣrib Flagga Statsvapen Valspråk: الله، الوطن، الملك Arabiska: Allah, al-watan, al-malik(Gud, hemlandet, kungen) Nationalsång: «النشيد الشريف» (Al-nashid al-sharif) — «Hymne Chérifien» läge HuvudstadRabat Största stad Casablanca Officiellt språk ArabiskaTamazight Demonym marockan[1] Statsskick konstitutionell m...

 

Newtownards

Newtownards en irlandais : Baile Nua na hArda en scots : Newton / Newtonairds Administration Pays Royaume-Uni Nation Irlande du Nord Comté Down District Ards and North Down Force de police Service de police d'Irlande du Nord Incendie Northern Ireland Fire and Rescue Service (en) Ambulance Northern Ireland Ambulance Service (en) Indicatif 028 Démographie Population 27 821 hab. (2001) Géographie Coordonnées 54° 35′ 28″ nord, 5° 40′&...

Theodore Kosloff

Russian-American ballet dancer, choreographer, and actor Theodore KosloffKosloff, 1920sBornFyodor Mikhailovich KozlovJanuary 22, 1882Moscow, Russian EmpireDiedNovember 22, 1956(1956-11-22) (aged 74)Los Angeles, U.S.Burial placeValhalla Memorial Park CemeteryOther namesTheodor KosloffOccupation(s)Ballet dancer, choreographer, actor Theodore Kosloff (born Fyodor Mikhailovich Kozlov, ‹See Tfd›Russian: Фёдор Михайлович Козлов; January 22, 1882 – November 2...

 

Earl Morrall

Earl MorrallMorrall nel 1965Nazionalità Stati Uniti Altezza185 cm Peso93 kg Football americano RuoloQuarterback CarrieraGiovanili  Michigan State Spartans Squadre di club 1956 San Francisco 49ers1957-1958 Pittsburgh Steelers1958-1964 Detroit Lions1965-1967 New York Giants1968-1971 Baltimore Colts1972-1976 Miami Dolphins Palmarès Trofeo Vittorie Super Bowl 3 MVP della NFL 1 Selezioni al Pro Bowl 2 Vedi maggiori dettagliStatistiche aggiornate al 10 ...

 

List of Mongol states

This article possibly contains original research. Please improve it by verifying the claims made and adding inline citations. Statements consisting only of original research should be removed. (June 2023) (Learn how and when to remove this message) This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: List of Mongol states – news �...

Stoke Newington

Area in London, England Not to be confused with Newington, in the London Borough of Southwark. This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Stoke Newington – news · newspapers · books · scholar · JSTOR (March 2021) (Learn how and when to remove this message) Human settlement in EnglandStoke NewingtonStoke...

 

Lord High Treasurer

English government position This article is about the post in England, Great Britain and the United Kingdom. For the corresponding post in Ireland, see Lord High Treasurer of Ireland. For the corresponding post in Scotland, see Lord High Treasurer of Scotland. For the corresponding post in Sweden, see Lord High Treasurer of Sweden. Lord High Treasurer of the United KingdomCharles Talbot, 1st Duke of Shrewsbury, last holder of the office as Lord High Treasurer of Great BritainHis Majesty's Tre...