Wilkie's professional career began in 1937. After winning 13 games for the 1940 Seattle Rainiers of the Pacific Coast League, Wilkie was acquired by the Pirates that August. He appeared in 26 games during the 1941 season, and another 35 games in 1942. During his rookie campaign, he pitched the only shutout of his MLB career, blanking the Philadelphia Phillies 5–0 on six hits on June 9, 1941.[1]
During his time in the Major Leagues, Wilkie allowed 215 hits and 80 bases on balls in 194 innings pitched, with 37 strikeouts, three complete games and three saves. He then returned to minor league baseball, playing through 1951.