Motozane married the daughter of Fujiwara no Tadataka, whom he later divorced, and remarried to Taira no Moriko, the fourth daughter of Taira no Kiyomori. At the age of 16 he assumed the position of kampaku, regent, to Emperor Nijō, becoming the head of the Fujiwara clan. He died at the age of 24, a year after he became sesshō, or regent, to Emperor Rokujō, leaving his wife Taira no Moriko windowed at the age of 12.
His descendants later came to be known as the Konoe family, one of the Five sessho families, taking its name from Motozane's Kyoto residence on Konoe-Ōji (近衛大道) road.[1]