From South Catlettsburg to Louisa it follows the original routing of U.S. 23. It intersects KY-180, which parallels I-64, after 6.4 miles (10.3 km). At this intersection, you turn right to stay on KY-3. The road continues 8 miles (13 km) to the Lawrence County line. In Lawrence County, it passes KY-1 and KY-1185, which takes you to Yatesville Lake. It then continues into downtown Louisa toward Inez and on to Prestonsburg.