This station received its original construction permit from the FCC on August 9, 1996.[4] The new station was assigned the call letters KAQX by the FCC on October 25, 1996.[1] KAQX received its license to cover from the FCC on February 5, 1999.[5]
The station was assigned the current call sign by the FCC on June 17, 1999.[1]
On January 5, 2012, KYSF changed its format from contemporary hits to EMF's K-Love contemporary Christian format.
On February 11, 2014, KYSF moved from 102.9 FM to 97.5 FM. The station was licensed to operate at 97.5 FM on January 13, 2015. By 2018, KYSF was broadcasting K-Love's sister station feed, Air 1 which flipped formats to Christian Worship in January 2019.