Ossai was born in Ketu Ijaniki, Lagos, Nigeria, and lived there until his family moved to Conroe, Texas when he was 10.[1]
He attended Oak Ridge High School, where he played basketball and football and was a two-time all-district and academic all-district honoree. As a senior, he recorded 58 tackles, eight sacks, 15 tackles for loss and three forced fumbles and was named first-team All-District 12-6A, and first-team All-Greater Houston by the Houston Chronicle.[2] Ossai was rated a four-star recruit and committed to play college football at Texas over offers from Texas A&M, Notre Dame and Oregon.[3]
As a true freshman, Ossai played in all 14 of the Longhorns' games with two starts and made 20 total tackles with one a sack and a forced fumble.[5][6][7]
He led the team with 62 tackles in his sophomore season while also recording five sacks, two interceptions, one pass broken up, one forced fumble and also blocked a kick.[8] In the postseason, he was the 2019 Alamo Bowl Defensive MVP. In the following spring, he made the Big 12 Commissioner’s Honor Roll.[4]
Ossai was named to the Bronko Nagurski Trophy, Chuck Bednarik Award and Lott IMPACT Trophy watchlists entering his junior season.[9] That year, he had 55 tackles, 15.5 tackles for loss, and 5 sacks on his way to being named first team All Big-12 and an All-American.[10] On 14 December 2020, Ossai announced his decision to enter the 2021 NFL draft, choosing to forgo Texas' 2020 Bowl game and his senior season.[11]
Ossai was selected by the Cincinnati Bengals in the third round (69th overall) of the 2021 NFL Draft.[15] He signed his four-year rookie contract on 2 June 2021.[16] Ossai suffered a meniscus injury in the second preseason game.[17] He was placed on injured reserve on 31 August 2021, ending his season.[18]
In 2022, Ossai was named the backup right defensive end, behind Trey Hendrickson on the depth chart.[19] He made his NFL debut in the Bengals' 2022 regular season opener against the Pittsburgh Steelers. In Week 18 against the Baltimore Ravens, he recovered a fumble for a touchdown in the 27–16 victory.[20] He appeared in 16 regular season games and recorded 3.5 sacks, 17 total tackles, one pass defended, and two fumble recoveries.[21] In the AFC Championship Game against the Kansas City Chiefs, Ossai committed an unnecessary roughness penalty with eight seconds left in regulation on quarterback Patrick Mahomes resulting in a 15-yard penalty and much closer field goal attempt (45-yards) which kicker Harrison Butker converted to advance to the Super Bowl.[22][23]
In 2023, Ossai returned to his role as a substitute defensive end for the season, once again behind Hendrickson on the right side.[24] He recorded his first sack of the season in Week 13 against the Jacksonville Jaguars.[25]