Mitogen-activated protein kinase 8 (also known as JNK1) is a ubiquitous enzyme that in humans is encoded by the MAPK8 gene. The protein encoded by this...

c-Jun N-terminal kinases consist of ten isoforms derived from three genes: JNK1 (four isoforms), JNK2 (four isoforms) and JNK3 (two isoforms). Each gene...

group. Thus ERK1 and ERK2 both correspond to the Drosophila kinase rolled, JNK1, JNK2 and JNK3 are all orthologous to the gene basket in Drosophila. Although...

cytokines, and environmental stresses. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by...

ATPase or isopeptidase activities. MG132 activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. MG132 also inhibits NF-κB activation with an...

JNK1-associated membrane protein is a protein that in humans is encoded by the JKAMP gene. GRCh38: Ensembl release 89: ENSG00000050130 – Ensembl, May 2017...

in response to various environmental stresses or mitogenic stimuli. MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38 are substrates for MAP2K4, but MAPK1/ERK2 and...

broad groups. One group includes members of the MAPK pathways, including JNK1–3, ERK1/2 and p38 MAPK, which are activated by diverse cellular stresses...

interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and...

pathways. During the infection, CPXV is known to use MEK/ERK/1/2/Egr-1, JNK1/2, and PI3K/Akt pathways. Some of these pathways are not unique only to CPXV...

kinase 2 mitogen-activated protein kinase kinase, tyrosine kinase 2, c-jun, JNK1, Janus kinase 1, TNF-a, interleukin-6, heparin-binding growth factor-like...

pro- or anti-apoptotic (cell dependent) Regulation of some genes including JNK1 Contributes to nuclear splicing of pre-mRNA Crosslinking and adhesive properties...

activation of the JNK pathway. His group has used mouse models deficient in JNK1, JNK2, JNK3, MKK4, and MKK7 to study the roles of these kinases in vivo....

kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation". Molecular and Cellular Biology. 20 (7):...

MAP4K4 MAP4K4 Mitogen-activated protein kinase kinase kinase kinase 4 MAPK8 JNK1 Mitogen-Activated Protein Kinase 8 MAPRE1 MAPRE1 Microtubule-associated protein...

a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis". J. Biol. Chem. 277 (34): 30454–62. doi:10...

encoding enzyme Inositol-tetrakisphosphate 1-kinase JKAMP: encoding protein JNK1-associated membrane protein JPH4: encoding protein Junctophilin 4 LINC00520:...

1030-1043.2000. PMC 85220. PMID 10629060. Hu MC, Qiu WR, Wang YP (Nov 1997). "JNK1, JNK2 and JNK3 are p53 N-terminal serine 34 kinases". Oncogene. 15 (19):...

including the MAPKs. AIF-mediated redox signaling promotes the activation of JNK1, which in turn can trigger the cadherin switch. Apoptosis Parthanatos PDB:...

(lyso-PC) induces AP-1 activity and c-Jun N-terminal kinase activity (JNK1) by a protein kinase C-independent pathway. 3T3 mouse cells are hypertriploid...

(1998). "Guanine-nucleotide exchange protein C3G activates JNK1 by a ras-independent mechanism. JNK1 activation inhibited by kinase negative forms of MLK3...

It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator...

"Glutathione S-transferase P1-1 (GSTP1-1) inhibits c-Jun N-terminal kinase (JNK1) signaling through interaction with the C terminus". The Journal of Biological...

CDK-independent mechanisms. p57 can bind JNK1/SAPK, a stress-related kinase, and block its activity, protecting against JNK1-regulated apoptosis. CIP/KIP proteins...

role in the transduction mechanism of TNFR2 signal which activates both JNK1 and JNK2 pathways. It is also observed that cell death increases upon downregulation...

a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis". J. Biol. Chem. 277 (34): 30454–62. doi:10...

ELF-1-like factor (MEF)-induced MAB-21-like-1 (MAB21L1) expression through the JNK1 pathway". J. Cell. Biochem. 112 (8): 2051–61. doi:10.1002/jcb.23124. PMID 21465527...

PMC 154362. PMID 12702766. Song JJ, Lee YJ (Nov 2003). "Role of the ASK1-SEK1-JNK1-HIPK1 signal in Daxx trafficking and ASK1 oligomerization". The Journal of...

Dérijard B, Hibi M, Wu IH, Barrett T, Su B, Deng T, et al. (March 1994). "JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates...

SLC46A3 shows decreased gene expression following c-Jun N-terminal kinase 1 (JNK1) depletion, suggesting possible roles in insulin resistance as well as glucose/triglyceride...

(2002). "IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition". Mol. Cell. Biol. 22 (6): 1754–66...

by the kinases MSK1, ERK1, p38, FYN, MLTK, ERK2, and to a lesser extent JNK1 and JNK2. The genomic DNA of eukaryotic cells is wrapped around special protein...

PMID 12684070. Chang L, Jones Y, Ellisman MH, Goldstein LS, Karin M (2003). "JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation...

death domain protein TRADD and negatively regulates the activation of NF-κB, JNK1, p53 and WOX1 during stress response". BMC Mol. Biol. 8: 50. doi:10.1186/1471-2199-8-50...

PMID 11279207. Girardin SE, Yaniv M (2001). "A direct interaction between JNK1 and CrkII is critical for Rac1-induced JNK activation". EMBO J. 20 (13):...

a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis". The Journal of Biological Chemistry. 277...

(Thr) residue at position 148 is mediated by c-Jun N-terminal kinase (MAPK8; JNK1) and p38 MAPK. Phosphorylated ATF2 inhibits the formation with JDP2 in vitro...

(2002). "IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition". Mol. Cell. Biol. 22 (6): 1754–66...

1016/S0378-1119(97)00411-3. PMID 9373149. Hu MC, Qiu WR, Wang YP (1997). "JNK1, JNK2 and JNK3 are p53 N-terminal serine 34 kinases". Oncogene. 15 (19):...

62 (8): 2258–2260. PMID 11956080. Chang NS, Doherty J, Ensign A (2003). "JNK1 physically interacts with WW domain-containing oxidoreductase (WOX1) and...

PMC 2818871. PMID 20129055. Miotto, Benoit; Struhl, Kevin (2011-10-07). "JNK1 Phosphorylation of Cdt1 Inhibits Recruitment of HBO1 Histone Acetylase and...

Donin N, Fishelson Z (2009). "Involvement of the c-jun N-terminal kinases JNK1 and JNK2 in complement-mediated cell death". Mol. Immunol. 47 (2–3): 310–7...