Drew was appointed on September 2, 1918, as a Republican to the U.S. Senate to fill the vacancy caused by the death of Jacob H. Gallinger and served from September 2, to November 5, 1918, when a successor was elected. He was not a candidate for election and retired from active business pursuits. He died in Montclair, New Jersey in 1922; was interment in Summer Street Cemetery, Lancaster.