In enzymology, an iron—cytochrome-c reductase (created 1972 as EC 1.9.99.1, transferred 2014 to EC 1.9.98.1) is an enzyme that catalyzes the chemical reaction

ferrocytochrome c + Fe³⁺ ${\displaystyle \rightleftharpoons }$ ferricytochrome c + Fe²⁺

Thus, the two substrates of this enzyme are ferrocytochrome c and Fe³⁺, whereas its two products are ferricytochrome c and Fe²⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a heme group of donors with other acceptors.

The systematic name of this enzyme class is ferrocytochrome-c:Fe³⁺ oxidoreductase. This enzyme is also called iron-cytochrome c reductase.

This enzyme is part of the electron transport system of Ferrobacillus ferrooxidans. It employs one cofactor, iron.

• Yates MG, Nason A (1966). "Electron transport systems of the chemoautotroph Ferrobacillus ferrooxidans. II. Purification and properties of a heat-labile iron-cytochrome c reductase". J. Biol. Chem. 241 (21): 4872–80. PMID 4288725.