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ITK
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1SM2, 1SNU, 1SNX, 2E6I, 2LMJ, 2YUQ, 3MIY, 3MJ1, 3MJ2, 3QGW, 3QGY, 3T9T, 3V5J, 3V5L, 3V8T, 3V8W, 4HCT, 4HCU, 4HCV, 4KIO, 4L7S, 4M0Y, 4M0Z, 4M12, 4M13, 4M14, 4M15, 4MF0, 4MF1, 4PP9, 4PPA, 4PPB, 4PPC, 4PQN, 4QD6, 4RFM
Identifiers
Aliases	ITK, EMT, LPFS1, LYK, PSCTK2, IL2 inducible T-cell kinase, IL2 inducible T cell kinase
External IDs	OMIM: 186973; MGI: 96621; HomoloGene: 4051; GeneCards: ITK; OMA:ITK - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	157,255,185 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	46,280,342 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; thymus; ; blood; ; lymph node; ; appendix; ; spleen; ; epithelium of colon; ; bone marrow cells; ; superficial temporal artery; ; gallbladder;
	Top expressed in
	thymus; ; mesenteric lymph nodes; ; blood; ; spleen; ; granulocyte; ; submandibular gland; ; subcutaneous adipose tissue; ; perirhinal cortex; ; entorhinal cortex; ; Ileal epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; non-membrane spanning protein tyrosine kinase activity; metal ion binding; kinase activity; protein binding; protein tyrosine kinase activity; signaling receptor binding; ATP binding;
Cellular component	cytoplasm; cytosol; cell-cell junction; extrinsic component of cytoplasmic side of plasma membrane; nucleus;
Biological process	intracellular signal transduction; adaptive immune response; phosphorylation; NK T cell differentiation; transmembrane receptor protein tyrosine kinase signaling pathway; immune system process; cytokine production; activation of phospholipase C activity; Fc-epsilon receptor signaling pathway; protein phosphorylation; cellular defense response; regulation of cell population proliferation; peptidyl-tyrosine autophosphorylation; T cell receptor signaling pathway; T cell activation; signal transduction; interleukin-4 production; innate immune response; B cell receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3702
	16428
	ENSG00000113263
	ENSMUSG00000020395
	Q08881
	Q03526
	NM_005546
	NM_001281965; NM_001281966; NM_001281967; NM_001281968; NM_010583
	NP_005537
	NP_001268894; NP_001268895; NP_001268896; NP_001268897; NP_034713
	Wikidata
View/Edit Human	View/Edit Mouse

Tyrosine-protein kinase ITK/TSK also known as interleukin-2-inducible T-cell kinase or simply ITK, is a protein that in humans is encoded by the ITK gene.^[5] ITK is a member of the TEC family of kinases and is highly expressed in T cells.^[6]

Function

This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein is thought to play a role in T-cell proliferation and differentiation.^[7]^[8] ITK is functionally important for the development and effector function of T_h2 and T_h17 cells.^[6]

Mice lacking ITK were shown to not be susceptible to asthma.^[9]

Structure

This protein contains the following domains, which are often found in intracellular kinases:^[10]

N-terminus – PH (pleckstrin homology domain)
TH – Tec family homology domain (including Bruton's tyrosine kinase Cys-rich motif and Proline rich region)
SH3 – (Src homology 3)
SH2 – (Src homology 2)
C-terminus – tyrosine kinase, catalytic domain