HLA-B38

Further information: HLA-serotype tutorial
Illustration of HLA-B with peptide in the binding pocket.
HLA-B (alpha)-β2MG with bound peptide
major histocompatibility complex (human), class I, B38
Alleles B*3801, 3802, . .
Structure (See HLA-B)
Shared data
Locus chr.6 6p21.31

HLA-B38 (B38) is an HLA-B serotype. The serotype identifies the B*38 allele products of the HLA-B gene-locus.[1]

B38 is a split antigen of the broad antigen B16, and is a sister type of B39. The B*3801 allele is more common in Eastern, Southern and Southeastern Europe, while the B*3802 allele is more common in the Far East.

Serotype

Serotypes B38, B16, and B39 recognition of the
HLA B*39 gene products[2]
B*38 B38 B16 B39 Sample
allele % % % size (N)
*3801 94 1 1 2317
*3802 87 2 2 788
Alleles link-out to IMGT/HLA Databease at EBI

Alleles

HLA B*3801 frequencies
freq
ref. Population (%)
[3] Israel Ashk. and Non Ashk. Jews 6.9
Croatia 6.7
Italy North 6.7
Azores Central Islands 5.4
Sudanese 5.3
Czech Republic 4.7
Georgia Tbilisi Georgians 4.6
Macedonia (4) 4.6
Spain Eastern Andalusia 4.1
Georgia Svaneti Svans 3.8
New Mexico Canoncito Navajo 3.7
Bulgaria 3.6
Brazil Belo Horizonte 3.2
Romanian 3.2
Tunisia 3.0
Thailand 2.8
Israel Arab Druse 2.5
USA Caucasian (2) 2.5
Tunisia Tunis 2.3
Brazil 2.2
Indig. Australian Cape York Penin. 2.0
France South East 1.9
Georgia Tbilisi Kurds 1.7
Australia New South Wales 1.5
China Guangzhou 1.5
Mexico Guadalajara Mestizos (2) 1.5
China Yunnan Lisu 1.4
Jordan Amman 1.4
Morocco Nador Metalsa Class I 1.4
China South Han 1.2
Mexico Mestizos 1.2
Saudi Arabia Guraiat and Hail 1.2
Finland 1.1
USA North American Natives 1.1
American Samoa 1.0
China North Han 1.0
India North Hindus 1.0
Mexico Mixtec Oaxaca 1.0
Hong Kong Chinese 0.9
Ireland Northern 0.9
Cape Verde Southeastern Islands 0.8
China Beijing 0.8
Ireland South 0.8

Disease

A higher frequency of HLA-B38 was noted psoriatic arthritis patients with erythroderma.[4] Psoriatic arthritis is linked to MICA and/or B39 in other peoples.[5] In Pemphigus vulgaris a haplotype containing B38 was identified and found to be shared between Spanish and Jewish patients.[6] Linkage studies indicate a factor in the HLA-class I region is more greatly associated, with HLA-B38 so far the only linked allele[7]

HLA B*3802 frequencies
freq
ref. Population (%)
[3] Taiwan Tao 11.0
China Guangxi Maonan 8.3
China South Han 7.1
Singapore Javan. Indonesians 7.1
Singapore Chinese Han 6.4
Taiwan Minnan pop 1 6.4
China Guangzhou 6.0
Philippines Ivatan 6.0
Hong Kong Chinese 5.4
Singapore Chinese 4.7
Singapore Riau Malay 4.5
China Guangzhou Han 4.3
India West Bhils 4.0
Taiwan Hakka 3.6
Singapore Thai 3.5
Taiwan Siraya 2.9
Taiwan Pazeh 1.8
India Mumbai Marathas 1.2
South Korea pop 3 1.1
Taiwan Puyuma 1.0
Taiwan Saisiat 1.0
China Beijing 0.8
Brazil 0.7

References

  1. ^ Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.
  2. ^ derived from IMGT/HLA
  3. ^ a b Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.
  4. ^ Imre K, Koó E, Seszták M, Bosák V, Bitterova O (December 2006). "[Genetics in patients with psoriatic arthritis]". Orv Hetil (in Hungarian). 147 (50): 2415–9. PMID 17274187.
  5. ^ Eastmond CJ (May 1994). "Psoriatic arthritis. Genetics and HLA antigens". Baillière's Clinical Rheumatology. 8 (2): 263–76. doi:10.1016/S0950-3579(94)80018-9. PMID 8076387.
  6. ^ Loewenthal R, Slomov Y, Gonzalez-Escribano MF, et al. (April 2004). "Common ancestral origin of pemphigus vulgaris in Jews and Spaniards: a study using microsatellite markers". Tissue Antigens. 63 (4): 326–34. doi:10.1111/j.0001-2815.2004.00191.x. PMID 15009804.
  7. ^ Slomov E, Loewenthal R, Goldberg I, Korostishevsky M, Brenner S, Gazit E (August 2003). "Pemphigus vulgaris in Jewish patients is associated with HLA-A region genes: mapping by microsatellite markers". Hum. Immunol. 64 (8): 771–9. doi:10.1016/S0198-8859(03)00092-2. PMID 12878355.