HLA-B14

Further information: HLA-serotype tutorial
Illustration of HLA-B with peptide in the binding pocket.
HLA-B (alpha)-β2MG with bound peptide
major histocompatibility complex (human), class I, B14
Alleles B*1401, 1402 . .
Structure (See HLA-B)
Shared data
Locus chr.6 6p21.31

HLA-B14 (B14) is a HLA-B serotype. The serotype identifies the B*45 gene-allele protein products of HLA-B.[1]

B14 is a broad antigen composed to two, B64 and B65, split antigens. In the case of B14 the recognition of the broad antigen is more useful than split antigen recognition because of the relatively poor discrimination of the split antigens (see Table below).

Serotype

B14, B64, B65 serotype recognition of some
HLA B*14 allele-group gene products [2]
B*14 B14 B64 B65 Sample
allele % % % size (N)
*1401 72 10 10 1006
*1402 71 2 25 2244
*1403 50 35 40
Alleles link-out to IMGT/HLA Databease at EBI

HLA-B64

This serotype does not have good recognition of any of the alleles, relatively speaking recognizes B*1401 better.

HLA-B65

This serotype recognizes B*1402 and B*1403 but less so than B14 and to a minor degree it recognized B*1401.

References

  1. ^ Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.
  2. ^ Robinson J, Waller MJ, Fail SC, Marsh SG (2006). "The IMGT/HLA and IPD databases". Hum. Mutat. 27 (12): 1192–9. doi:10.1002/humu.20406. PMID 16944494.