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GSTM1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1GTU, 1XW6, 1XWK, 1YJ6, 2F3M
Identifiers
Aliases	GSTM1, GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, H-B, MU, MU-1, glutathione S-transferase mu 1
External IDs	OMIM: 138350; MGI: 95861; HomoloGene: 121492; GeneCards: GSTM1; OMA:GSTM1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	109,709,039 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	107,893,769 bp
RNA expression pattern
	Top expressed in
	smooth muscle tissue; ; gastric mucosa; ; mucosa of transverse colon; ; apex of heart; ; left uterine tube; ; testicle; ; duodenum; ; anterior pituitary; ; right lobe of liver; ; right ovary;
	Top expressed in
	uterus; ; ovary; ; adrenal gland; ; white adipose tissue; ; esophagus; ; urinary bladder; ; lung; ; muscle of thigh; ; stomach; ; testicle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	enzyme binding; glutathione binding; protein homodimerization activity; transferase activity; glutathione transferase activity;
Cellular component	cytoplasm; cytosol; intercellular bridge;
Biological process	xenobiotic catabolic process; nitrobenzene metabolic process; cellular detoxification of nitrogen compound; glutathione metabolic process; metabolism; glutathione derivative biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	2944
	14863
	ENSG00000134184
	ENSMUSG00000040562
	P09488
	P15626
	NM_000561; NM_146421
	NM_008183
	NP_000552; NP_666533
	NP_032209
	Wikidata
View/Edit Human	View/Edit Mouse

Glutathione S-transferase Mu 1 (gene name GSTM1) is a human glutathione S-transferase.

Function

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a cytoplasmic glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress, by conjugation with glutathione.

The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3, and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins, as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene.^[5]