Studies involve understanding the regulation of Cancer Stem Cells during tumor metastasis in Breast Cancer and discovery of new targets and target based therapeutic agents addressing drug resistant cancers.
Dr. Fayaz Ahmad Malik is an Indian pharmacologist, cancer biologist and a scientist at the Indian Institute of Integrative Medicine of the Council of Scientific and Industrial Research. He is known for his studies on investigating the regulatory mechanisms of Cancer Stem Cells during tumor metastasis. His studies also involve the identification of signaling networks conferring resistance to current anti-cancer therapies. His discovery of new anticancer agents holds a number of patents for the processes he has developed. The Department of Biotechnology of the Government of India awarded him the National Bioscience Award for Career Development, one of the highest Indian science awards, for his contributions to Biosciences, in 2014.[1]
Fayaz Malik, after securing a master's degree in biotechnology and a PhD,.[2] He started his career by joining the Indian Institute of Integrative Medicine of the Council of Scientific and Industrial Research where he is a senior scientist of the Cancer Research and Drug Discovery group.[3] His major research focus remains to understand the critical regulatory biological mechanisms predisposed to the failure of current therapies, acquired resistance, and the onset of metastasis by exploring cellular catabolic machinery and regulatory networks of Cancer Stem Cells in subtypes of breast cancer.[4] He has also developed many processes for which he holds the patents.[5][6][7] His studies have been documented by way of a number of articles[8][note 1] and Google Scholar, an online repository of scientific articles has listed 70 of them.[9] Besides, he has contributed chapters to books published by others.[10] He has also participated in various seminars and conferences to give invited speeches.[11][12]
Pathania, Anup Singh; Guru, Santosh Kumar; Verma, M.K.; Sharma, Chetna; Abdullah, Sheikh Tasduq; Malik, Fayaz; Chandra, Suresh; Katoch, Meenu; Bhushan, Shashi (2013). "Disruption of the PI3K/AKT/mTOR signaling cascade and induction of apoptosis in HL-60 cells by an essential oil from Monarda citriodora". Food and Chemical Toxicology. 62: 246–254. doi:10.1016/j.fct.2013.08.037. PMID23994707.
Malik, Fayaz; Korkaya, Hasan; Clouthier, Shawn G.; Wicha, Max S. (12 October 2012). "Breast Cancer Heterogeneity: Need to Review Current Treatment Strategies". Current Breast Cancer Reports. 4 (4): 225–231. doi:10.1007/s12609-012-0093-5. S2CID72596197.
Khajuria, Anamika; Gupta, Amit; Singh, Surjeet; Malik, Fayaz; Singh, Jaswant; Suri, K.A.; Satti, N.K.; Qazi, G.N.; Srinivas, V.K. (2007). "RLJ-NE-299A: A new plant based vaccine adjuvant". Vaccine. 25 (14): 2706–2715. doi:10.1016/j.vaccine.2006.06.036. PMID16872726.
Books/Chapters
Malik, Fayaz; Korkaya, Hasan; Clouthier, Shawn G.; Wicha, Max S. (2015). "Regulation of Breast Cancer Stem Cells by Mesenchymal Stem Cells in the Metastatic Niche". Principles of Stem Cell Biology and Cancer. pp. 123–143. doi:10.1002/9781118670613.ch7. ISBN9781118670613.
Pathania, Anup S.; Makhdoomi, Ubaid S.; Malik, Fayaz A. (2017). "Genetic and Epigenetic Regulation of Autophagy in Cancer". Genome Analysis and Human Health. pp. 1–29. doi:10.1007/978-981-10-4298-0_1. ISBN978-981-10-4297-3.
Korkaya, Hasan; Malik, Fayaz (2013). "Breast Cancer Stem Cells: Responsible for Therapeutic Resistance and Relapse?". Breast Cancer Metastasis and Drug Resistance. pp. 385–398. doi:10.1007/978-1-4614-5647-6_21. ISBN978-1-4614-5646-9.
Jaswant, Singh; Malik, Fayaz; Qazi, G. N. (2008). "Protective role of tea against cancer and infectious diseases through immune activation". In Jain, N. K.; Weisburger, John; Maqsood, Siddiqi (eds.). Economic crisis in tea industry : strategies for scientific management. Houston: Studium Press LLC. ISBN978-1-933699-37-0.
^N. K. Jain, John Weisburger, Maqsood Siddiqi; Jaswant Singh, Fayaz Malik Fayaz Malik Fayaz Malik and G. N. Qazi (Chapter authors) (2008). "Protective role of tea against cancer and infectious diseases through immune activation". Economic crisis in tea industry : strategies for scientific management. Houston, Tex.: Studium Press LLC. ISBN9781933699370. OCLC262700162.{{cite book}}: CS1 maint: multiple names: authors list (link)