The enzyme endoglycosylceramidase (EC 3.2.1.123) catalyzes the following chemical reaction:

oligoglycosylglucosylceramide + H₂O ${\displaystyle \rightleftharpoons }$ ceramide + oligoglycosylglucose

This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name is oligoglycosylglucosylceramide glycohydrolase. Other names in common use include endoglycoceramidase, EGCase, and glycosyl-N-acetyl-sphingosine 1,1-β-D-glucanohydrolase.

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 2OSW, 2OSX, 2OSY, 2OYK, 2OYL, and 2OYM.

• Ito M, Yamagata T (1986). "A novel glycosphingolipid-degrading enzyme cleaves the linkage between the oligosaccharide and ceramide of neutral and acidic glycosphingolipids". J. Biol. Chem. 261 (30): 14278–82. doi:10.1016/S0021-9258(18)67015-2. PMID 3771534.