Smith redshirted his true freshman season and did not play in any games as a redshirt freshman.[3] He started seeing playing time as a redshirt sophomore and finished the season with 19 tackles, 10.5 tackles for loss, 7.5 sacks, and a forced fumble.[4] Smith was named first-team All-Missouri Valley Football Conference and a first-team FCS All-American by the AFCA after recording 63 total tackles, 14 sacks, 21.5 tackles for loss and five forced fumbles.[5] Smith was named the Preseason Defensive Player of the Year before announcing that he would forgo his redshirt senior season, which was to be played in the spring due to Covid-19, and prepare for the 2021 NFL draft.[6] Smith played in the 2021 Senior Bowl.[7]
Smith was selected in the fourth round with the 116th overall pick of the 2021 NFL Draft by the New York Giants.[11] Smith signed his four-year rookie contract with the Giants on May 25, 2021.[12] He was placed on injured reserve on September 1, 2021 to start the season.[13] On November 6, 2021, Smith was activated from injured reserve.[14] On January 5, 2022, Smith was placed on injured reserve with a neck injury.[15]
On August 31, 2022, Smith was placed on injured reserve.[16] He was activated from injured reserve on October 29.[17] He was placed back on injured reserve on December 16.
On July 25, 2023, Smith was waived by the Giants.[18]
On November 22, 2023, Smith was signed to the Las Vegas Raiders practice squad.[21] He signed a reserve/future contract on January 8, 2024.[22] He was waived/injured on August 27, 2024.[23]
Cleveland Browns
On September 25, 2024, Smith was signed to the Cleveland Browns practice squad.[24] He was promoted to the active roster on November 16.[25] He was waived on November 27, and re-signed to the practice squad.[26]