The region is covered by 23 municipalities being Guarne the closest to the city of Medellín
located some 24 km away. The largest municipality of this region is Sonsón with a total area of 1,323 km2 and the smallest is Argelia.
The population in this region is distributed evenly between the urban and rural areas with 43% of the people living in the urban centers and 57% living in the countryside.