On September 7, 2011, DePalma signed to the New York Giants' practice squad.[2] He re-signed with the Giants on February 8, 2012 and was waived on August 31.[3] DePalma re-signed to the Giants’ practice squad on November 22, 2012.
San Diego Chargers
On April 8, 2013, DePalma was signed by the San Diego Chargers. On August 27, 2013, he was placed on the reserve/injured list.[4] On August 31, 2013, he was waived with an injury settlement. On November 26, 2013, DePalma was signed to the Chargers' practice squad.