In 1662, the third count died without issue and this title was inherited by his sister's grandson, Luís de Lencastre (who descended from InfanteGeorge of Lencastre, Duke of Coimbra).
Later, in the 18th century, due to the 5th count's marriage to Maria Sofia de Lencastre (heiress of the House of Abrantes), the family reunited all the estates and honours within the same House, which became a reference among the Portuguese aristocracy.
List of counts of Vila Nova de Portimão
Martinho Castelo Branco (c.1460- ? );
Manuel de Castelo Branco (1550- ?), his grandson;
Gregório Taumaturgo de Castelo-Branco (c.1600-1662), his son;
Luis de Lancastre (1644-1704), his grand-nephew;
Pedro de Lancastre (1697-1752), his son;
José Maria de Lancastre e Tavora (1742-1771), his grandson;