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Coriamyrtin^[1]
Names
	IUPAC name (1S,2R,3S,5R,6R,7R,9S,12R)-2-Hydroxy-7-methyl-12-prop-1-en-2-ylspiro[4,10-dioxatetracyclo[7.2.1.02,7.03,5]dodecane-6,2'-oxirane]-11-one
	Other names Coriamyrtine
Identifiers
3D model (JSmol)	Interactive image;
PubChem CID	442189;
CompTox Dashboard (EPA)	DTXSID50948589 ;
	InChI InChI=1S/C15H18O5/c1-6(2)8-7-4-13(3)14(5-18-14)10-11(20-10)15(13,17)9(8)12(16)19-7/h7-11,17H,1,4-5H2,2-3H3/t7-,8+,9+,10+,11-,13-,14+,15-/m0/s1 Key: BWWDLKVKPVKBGJ-TWMZOSGRSA-N;
	SMILES CC(=C)C1C2CC3(C4(CO4)C5C(C3(C1C(=O)O2)O)O5)C;
Properties
Chemical formula	C15H18O5
Molar mass	278.304 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Coriamyrtin is a toxic γ-lactone naturally present in a multitude of plants.

Natural occurrence

Coriamyrtin can be found in Scurrula parasitica,^[2] Coriaria microphylla,^[3] and certain other plants.

Toxicity

Coriamyrtin is a convulsant.^[4] It appears to act via antagonism of GABA_A receptors.^[5] Poisoning is usually from ingestion of parts of the plants containing it. A case of poisoning was able to be treated with repeated administration of diazepam, an anticonvulsant.^[6]

References

^ "Coriamyrtin".
^ PubChem. "Scurrula parasitica". pubchem.ncbi.nlm.nih.gov. Retrieved 2024-02-11.
^ PubChem. "Coriaria microphylla". pubchem.ncbi.nlm.nih.gov. Retrieved 2024-02-11.
^ "T3DB: Coriamyrtin". www.t3db.ca. Retrieved 2024-02-11.
^ Pérez, Claudia; Becerra, José; Manríquez-Navarro, Paula; Aguayo, Luis Gerardo; Fuentealba, Jorge; Guzmán, José Leonardo; Joseph-Nathan, Pedro; Jiménez, Verónica; Muñoz, Marcelo Andrés; Silva, Mario (2011). "Inhibitory activities on mammalian central nervous system receptors and computational studies of three sesquiterpene lactones from Coriaria ruscifolia subsp. ruscifolia". Chemical & Pharmaceutical Bulletin. 59 (2): 161–165. doi:10.1248/cpb.59.161. ISSN 1347-5223. PMID 21297293.
^ de Haro, Luc; Pommier, Philip; Tichadou, Lucia; Hayek-Lanthois, Maryvonne; Arditti, Jocelyne (November 2005). "Poisoning by Coriaria myrtifolia Linnaeus: a new case report and review of the literature". Toxicon. 46 (6): 600–603. Bibcode:2005Txcn...46..600D. doi:10.1016/j.toxicon.2005.06.026. ISSN 0041-0101. PMID 16165183.

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[1] "Coriamyrtin".

[2] PubChem. "Scurrula parasitica". pubchem.ncbi.nlm.nih.gov. Retrieved 2024-02-11.

[3] PubChem. "Coriaria microphylla". pubchem.ncbi.nlm.nih.gov. Retrieved 2024-02-11.

[4] "T3DB: Coriamyrtin". www.t3db.ca. Retrieved 2024-02-11.

[5] Pérez, Claudia; Becerra, José; Manríquez-Navarro, Paula; Aguayo, Luis Gerardo; Fuentealba, Jorge; Guzmán, José Leonardo; Joseph-Nathan, Pedro; Jiménez, Verónica; Muñoz, Marcelo Andrés; Silva, Mario (2011). "Inhibitory activities on mammalian central nervous system receptors and computational studies of three sesquiterpene lactones from Coriaria ruscifolia subsp. ruscifolia". Chemical & Pharmaceutical Bulletin. 59 (2): 161–165. doi:10.1248/cpb.59.161. ISSN 1347-5223. PMID 21297293.

[6] Haro, Luc; Pommier, Philip; Tichadou, Lucia; Hayek-Lanthois, Maryvonne; Arditti, Jocelyne (November 2005). "Poisoning by Coriaria myrtifolia Linnaeus: a new case report and review of the literature". Toxicon. 46 (6): 600–603. Bibcode:2005Txcn...46..600D. doi:10.1016/j.toxicon.2005.06.026. ISSN 0041-0101. PMID 16165183.

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