In enzymology, a coniferyl-aldehyde dehydrogenase (EC 1.2.1.68) is an enzyme that catalyzes the chemical reaction

coniferyl aldehyde + H₂O + NAD(P)+ ${\displaystyle \rightleftharpoons }$ ferulate + NAD(P)H + 2 H⁺

The 4 substrates of this enzyme are coniferyl aldehyde, H₂O, NAD⁺, and NADP⁺, whereas its 4 products are ferulate, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is coniferyl aldehyde:NAD(P)+ oxidoreductase.

• Achterholt S, Priefert H, Steinbuchel A (1998). "Purification and characterization of the coniferyl aldehyde dehydrogenase from Pseudomonas sp. Strain HR199 and molecular characterization of the gene". J. Bacteriol. 180 (17): 4387–91. PMC 107445. PMID 9721273.