Choclo virus

Orthohantavirus chocloense
Virus classification Edit this classification
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Negarnaviricota
Class: Ellioviricetes
Order: Bunyavirales
Family: Hantaviridae
Genus: Orthohantavirus
Species:
Orthohantavirus chocloense
Synonyms[1][2]
  • Choclo orthohantavirus
  • Choclo virus

Choclo virus (CHOV) is a single-stranded, negative-sense RNA zoonotic New World hantavirus. It was first isolated in 1999 in western Panama. The finding marked the first time Hantavirus pulmonary syndrome (HPS) was found in Central America.[3]

During this outbreak, a high seroprevalence was found among the general population, suggesting that this virus has an extremely low pathogenicity and causes sub-clinical to mild symptoms. This was confirmed in a study that infected hamsters with CHOV. All of the hamsters tested positive for CHOV, but none exhibited any symptoms.[4]

Natural reservoir

The virus was isolated from the northern pygmy rice rat in El Choclo in the Los Santos Province in western Panama.[citation needed]

Transmission

Choclo virus has not been shown to transfer from person-to-person. Transmission by aerosolized rodent excreta still remains the only known way the virus is transmitted to humans. In general, droplet and/or fomite transfer has not been shown in the hantaviruses in general, in either the hemorrhagic or pulmonary forms.[5][6][7]

Epidemiology

There were a total of eleven cases reported but only nine serologically confirmed cases of Choclo virus found in this outbreak. A serologic survey of residents in the area revealed a 13% antibody prevalence. No person-to-person transmissions were found. There were no fatalities among serologically confirmed cases. There were three fatalities among those who tested negative for the virus. Before this outbreak, there were no documented cases of human hantavirus infections in Central America.[7][8][9]

See also

References

  1. ^ "Genus: Orthohantavirus". International Committee on Taxonomy of Viruses. Retrieved 6 January 2025.
  2. ^ "History of the taxon: Species: Orthohantavirus chocloense (2023 Release, MSL #39)". ictv.global. International Committee on Taxonomy of Viruses. Retrieved 6 January 2025.
  3. ^ Nelson, R; Cañate, R; Pascale, JM; Dragoo, JW; Armien, B; Armien, AG; Koster, F (Sep 2010). "Confirmation of Choclo virus as the cause of hantavirus cardiopulmonary syndrome and high serum antibody prevalence in Panama". J Med Virol. 82 (9): 1586–93. doi:10.1002/jmv.21864. PMC 2927102. PMID 20648614.
  4. ^ Eyzaguirre, EJ; Milazzo, ML; Koster, FT; Fulhorst, CF (Apr 2008). "Choclo virus infection in the Syrian golden hamster". Am J Trop Med Hyg. 78 (4): 669–74. doi:10.4269/ajtmh.2008.78.669. PMC 2689364. PMID 18385367.
  5. ^ Peters, C.J. (2006). "Emerging Infections: Lessons from the Viral Hemorrhagic Fevers". Transactions of the American Clinical and Climatological Association. 117: 189–197. PMC 1500910. PMID 18528473.
  6. ^ Crowley, J.; Crusberg, T. "Ebola and Marburg Virus Genomic Structure, Comparative and Molecular Biology". Dept. of Biology & Biotechnology, Worcester Polytechnic Institute. Archived from the original on 2013-10-15.
  7. ^ a b Bayard, Vicente; Kitsutani, Paul T.; Barria, Eduardo O.; Luis, A. Ruedas; et al. (September 2004). "Outbreak of Hantavirus Pulmonary Syndrome, Los Santos, Panama, 1999–2000". Emerg Infect Dis. 10 (9): 1635–1642. doi:10.3201/eid1009.040143. PMC 3320309. PMID 15498167.
  8. ^ Vincent, MJ; Quiroz, E; Gracia, F; Sanchez, AJ; Ksiazek, TG; Kitsutani, PT; et al. (2000). "Hantavirus pulmonary syndrome in Panama; identification of novel hantaviruses and their likely reservoirs". Virology. 277 (1): 14–9. doi:10.1006/viro.2000.0563. PMID 11062031.
  9. ^ Bayard, V; Kitsutani, PT; Barria, EO; Ruedas, LA; Tinnin, DS; Muñoz, C; de Mosca, IB; Guerrero, G; Kant, R; Garcia, A; Caceres, L; Gracio, FG; Quiroz, E; de Castillo, Z; Armien, B; Libel, M; Mills, JN; Khan, AS; Nichol, ST; Rollin, PE; Ksiazek, TG; Peters, CJ (2004). "Outbreak of Hantavirus Pulmonary Syndrome, Los Santos, Panama, 1999–2000". Emerging Infect. Dis. 10 (9): 1635–42. doi:10.3201/eid1009.040143. PMC 3320309. PMID 15498167.