In 1600, he sided with Ishida Mitsunari and commanded 6,600 men. His troops fought against Ikeda Terumasa at the Battle of Sekigahara (though he saw very little action) and was afterwards deprived of his fief despite sending an apology to Tokugawa Ieyasu. That same year, he had ordered the execution of his elder brother Tsuno Chikatada, who had questioned his right to be Motochika's heir, as ruler of Tosa Province.
In 1614, he went to join the defenders of Osaka Castle against the Tokugawa, he arriving there the same day as Sanada Yukimura. His Chōsokabe contingent fought very well in both the Winter and Summer Osaka Campaigns. After the fall of Osaka, Morichika attempted to flee but was apprehended at Hachiman-yama by Hachisuka men. He and his sons were beheaded on May 11, 1615, following the defeat of the Toyotomi and Chōsokabe forces at the Battle of Tennōji.[1]