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Central canal of spinal cord
Central canal of spinal cord
	Cross-section through cervical spinal cord.
Details
Location	Centre of the spinal cord
Identifiers
Latin	canalis centralis medullae spinalis
TA98	A14.1.02.019
TA2	6127
FMA	78497
	Anatomical terminology [edit on Wikidata]

The central canal (also known as spinal foramen or ependymal canal) is the cerebrospinal fluid-filled space that runs through the spinal cord.^[1] The central canal lies below and is connected to the ventricular system of the brain, from which it receives cerebrospinal fluid, and shares the same ependymal lining. The central canal helps to transport nutrients to the spinal cord as well as protect it by cushioning the impact of a force when the spine is affected.

The central canal represents the adult remainder of the central cavity of the neural tube. It generally occludes (closes off) with age.^[2]

Structure

The central canal below at the ventricular system of the brain, beginning at a region called the obex where the fourth ventricle, a cavity present in the brainstem, narrows.

The central canal is located in the anterior third of the spinal cord in the cervical and thoracic regions. In the lumbar spine it enlarges and is located more centrally. At the conus medullaris, where the spinal cord tapers, it is located more posteriorly.

Terminal ventricle

The terminal ventricle (ventriculus terminalis, fifth ventricle or ampulla caudalis) is the widest part of the central canal of the spinal cord that is located at or near the conus medullaris.^[3]^{[unreliable source?]} It was described by Stilling in 1859 and Krause in 1875.^[4] Krause introduced the term fifth ventricle after observation of normal ependymal cells.^[4] The central canal expands as a fusiform terminal ventricle, and approximately 8–10 mm in length in the conus medullaris (or conus terminalis).^[5] Although the terminal ventricle is visible in the fetus and children, it is usually absent in adults.^[3]

Sometimes, the terminal ventricle is observed by MRI or ultrasound in children less than 5 years old.^[6]

Microanatomy

The central canal shares the same ependymal lining as the ventricular system of the brain.

The canal is lined by ciliated, column-shaped cells, outside of which is a band of gelatinous substance, called the substantia gelatinosa of Rolando also substantia gelatinosa centralis or central gelatinous substance of spinal cord. This gelatinous substance consists mainly of neuroglia, but contains a few nerve cells and fibers; it is traversed by processes from the deep ends of the columnar ciliated cells which line the central canal.

Development

The central canal represents the adult remainder of the central cavity of the neural tube. It generally occludes (closes off) with age.^[2]

Function

The central canal carries cerebrospinal fluid (CSF), which it receives from the ventricular system of the brain. The central canal helps to transport nutrients to the spinal cord as well as protect it by cushioning the impact of a force when the spine is affected.

Clinical significance

Syringomyelia is a disease caused by the blockage of the central canal. Blockage of the central canal usually occurs at the lower cervical and upper thoracic levels. This typically damages white matter fibers that cross in anterior white commissure, leading to the loss of temperature, pain, and motor function at the affected levels on side opposite to the damage.

Other relevant conditions include:

Spina bifida
Arnold-Chiari syndrome
Spinal tumor
Myelomeningocele
Syringomyelia
Hydromyelia. In hydromyelia, a dilation of the central canal of the spinal cord is caused by an increase of cerebrospinal fluid.^[7]
Syringohydromyelia (i.e., both Syringomyelia and Hydromyelia)^[7]
Tethered cord

In some cases, the terminal ventricle may cause clinical symptoms due to its expansion.

References

This article incorporates text in the public domain from page 753 of the 20th edition of Gray's Anatomy (1918)

^ Saker, Erfanul; Henry, Brandon M; Tomaszewski, Krzysztof A; Loukas, Marios; Iwanaga, Joe; Oskouian, Rod J; Tubbs, R. Shane (2016). "The Human Central Canal of the Spinal Cord: A Comprehensive Review of its Anatomy, Embryology, Molecular Development, Variants, and Pathology". Cureus. 8 (12): e927. doi:10.7759/cureus.927. ISSN 2168-8184. PMC 5234862. PMID 28097078.
^ ^a ^b Yasui K, Hashizume Y, Yoshida M, Kameyama T, Sobue G (1999). "Age-related morphologic changes of the central canal of the human spinal cord". Acta Neuropathol. 97 (3): 253–9. doi:10.1007/s004010050982. PMID 10090672. S2CID 21008308.
^ ^a ^b "ventriculus terminalis". radsource.us. July 2008.
^ ^a ^b Liccardo G, Ruggeri F, De Cerchio L, Floris R, Lunardi P (June 2005). "Fifth ventricle: an unusual cystic lesion of the conus medullaris". Spinal Cord. 43 (6): 381–4. doi:10.1038/sj.sc.3101712. PMID 15655569.
^ Williams & Warwick. Gray's Anatomy .THIRTY-SEVENTH EDITION.ISBN 0 443 04177 6^{[page needed]}
^ Celli P, D'Andrea G, Trillò G, Roperto R, Acqui M, Ferrante L (March 2002). "Cyst of the medullary conus: malformative persistence of terminal ventricle or compressive dilatation?". Neurosurgical Review. 25 (1–2): 103–6. doi:10.1007/s10143-001-0203-8. PMID 11954762. S2CID 2214756.
^ ^a ^b "imaging in syringohydromyelia". emedicine.medscape. 2018-04-25.

Tomsick T, Peak E, Wang L: Fluid-Signal Structures in the Cervical Spinal Cord on MRI: Anterior Median Fissure vs. Central Canal. AJNR 2017; 38:840–45

Tomsick T, Wang L, Zuccarello M, Ringer AJ. Fluid-signal structures in the cervical spinal cord on MRI in Chiari patients: Central canal or anterior median fissure? AJNR Am J Neuroradiol. 2021 Apr;42(4):801-806. doi: 10.3174/ajnr.A7046. Epub 2021 Mar 11.PMID: 33707286