Cell-cycle nonspecific antineoplastic agents (CCNS) refer to a class of pharmaceuticals that act as antitumor agents at all or any phases of the cell cycle.^[1]

Alkylating antineoplastic agent and anthracyclins are two examples.

• Alberts DS, Golde DW (November 1974). "DNA synthesis in multiple myeloma cells following cell cycle-nonspecific chemotherapy". Cancer Res. 34 (11): 2911–4. PMID 4424360.
• Ozawa S, Sugiyama Y, Mitsuhashi Y, Kobayashi T, Inaba M (1988). "Cell killing action of cell cycle phase-non-specific antitumor agents is dependent on concentration--time product". Cancer Chemother. Pharmacol. 21 (3): 185–90. doi:10.1007/bf00262767. PMID 3129204.