Carbazole 1,9a-dioxygenase

Carbazole 1,9a-dioxygenase
Identifiers
EC no.1.14.12.22
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
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NCBIproteins

Carbazole 1,9a-dioxygenase (EC 1.14.12.22, CARDO) is an enzyme with systematic name 9H-carbazole,NAD(P)H:oxygen oxidoreductase (2,3-hydroxylating).[1][2] This enzyme catalyses the following chemical reaction

9H-carbazole + NAD(P)H + H+ + O2 2'-aminobiphenyl-2,3-diol + NAD(P)+

Carbazole 1,9a-dioxygenase catalyses the first reaction in the pathway of carbazole degradation.

References

  1. ^ Nam JW, Nojiri H, Noguchi H, Uchimura H, Yoshida T, Habe H, Yamane H, Omori T (December 2002). "Purification and characterization of carbazole 1,9a-dioxygenase, a three-component dioxygenase system of Pseudomonas resinovorans strain CA10". Applied and Environmental Microbiology. 68 (12): 5882–90. Bibcode:2002ApEnM..68.5882N. doi:10.1128/aem.68.12.5882-5890.2002. PMC 134387. PMID 12450807.
  2. ^ Gai Z, Wang X, Liu X, Tai C, Tang H, He X, Wu G, Deng Z, Xu P (April 2010). "The genes coding for the conversion of carbazole to catechol are flanked by IS6100 elements in Sphingomonas sp. strain XLDN2-5". PLOS ONE. 5 (4): e10018. Bibcode:2010PLoSO...510018G. doi:10.1371/journal.pone.0010018. PMC 2848856. PMID 20368802.