Colony forming unit for megakaryocytes in the bone marrow
CFU-Meg is a colony forming unit .
Haematopoiesis in the bone marrow starts off from a haematopoietic stem cell (HSC) and this can differentiate into the myeloid and lymphoid cell lineages. In order to eventually produce a megakaryocyte , the haematopoietic stem cell must generate myeloid cells, so it becomes a common myeloid progenitor , CFU-GEMM . This in turn develops into CFU-Meg, which is the colony forming unit that leads to the production of megakaryocytes.[ 1] [ 2] [ 3]
Some sources prefer the term "CFU-Mega".[ 4]
See also
References
^ Kimura H, Ohkoshi T, Matsuda S, Uchida T, Kariyone S (1988). "Megakaryocytopoiesis in polycythemia vera: characterization by megakaryocytic progenitors (CFU-Meg) in vitro and quantitation of marrow megakaryocytes". Acta Haematol . 79 (1): 1–6. doi :10.1159/000205681 . PMID 3124455 . ^ Kimura H, Ishibashi T, Sato T, Matsuda S, Uchida T, Kariyone S (January 1987). "Megakaryocytic colony formation (CFU-Meg) in essential thrombocythemia: quantitative and qualitative abnormalities of bone marrow CFU-Meg". Am. J. Hematol . 24 (1): 23–30. doi :10.1002/ajh.2830240104 . PMID 3799592 . S2CID 20893511 . ^ Gallicchio VS, Hughes NK, Hulette BC, Noblitt L (December 1991). "Effect of interleukin-1, GM-CSF, erythropoietin, and lithium on the toxicity associated with 3'-azido-3'-deoxythymidine (AZT) in vitro on hematopoietic progenitors (CFU-GM, CFU-MEG, and BFU-E) using murine retrovirus-infected hematopoietic cells" . J. Leukoc. Biol . 50 (6): 580–6. doi :10.1002/jlb.50.6.580 . PMID 1940611 . S2CID 9700067 . [permanent dead link ] ^ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease . St. Louis, Mo: Elsevier Saunders. p. 621. ISBN 0-7216-0187-1
External links
