CFU-GM

CFU-GM
Lineage. Captions in Polish, but "GMP" visible near bottom center.
Details
Gives rise toMonoblasts and myeloblasts
LocationBone marrow
Functioncolony forming unit
Identifiers
MeSHD055014
THH2.00.04.3.02009
Anatomical terms of microanatomy

CFU-GM (Colony Forming Unit–Granulocyte–Macrophage[a]), also known as granulocyte–macrophage progenitor (GMP), is a colony forming unit. It is derived from CFU-GEMM. It is the precursor for monoblasts and myeloblasts. Production is stimulated by granulocyte macrophage colony-stimulating factor (GM-CSF).

Granulocytes

There is some controversy over which granulocytes derive from CFU-GM.

  • There is little disagreement that neutrophils come from CFU-GM.
  • Some sources state that basophils also derive from CFU-GM, but that eosinophils come from "CFU-Eos".[2]
  • Other sources state that basophils do not derive from CFU-GM, but from a distinct CFU, titled "CFU-Baso".[3]

See also

Notes

  1. ^ The "GM" can also stand for "Granulocyte-Monocyte".[1]

References

  1. ^ "Hem I WBC Morphology and Physiology". Archived from the original on December 25, 2008. Retrieved 2008-12-30.
  2. ^ Ganong, William F.; McPhee, Stephen J.; Lingappa, Vishwanath R. (2005). Pathophysiology of Disease: An Introduction to Clinical Medicine (Lange). McGraw-Hill Medical. p. 107. ISBN 0-07-144159-X.
  3. ^ Rudolph, Colin David (2003). Rudolph's pediatrics. New York: McGraw-Hill, Medical Pub. Division. p. 1563. ISBN 0-8385-8285-0.


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