The commune lies on the left bank of the river Tisza, on the border with Ukraine, across from the village of Hrushovo [uk]. To the southwest is Piatra Săpânței Peak (941 m (3,087 ft)), in the Oaș Mountains.
Câmpulung la Tisa is located in the northern part of the county, 13 km (8.1 mi) northwest of Sighetu Marmației and 76 km (47 mi) north of the county seat, Baia Mare. It is traversed by national roadDN19 [ro], which runs from Oradea to Sighetu Marmației.