In enzymology, a butanal dehydrogenase (EC 1.2.1.57) is an enzyme that catalyzes the chemical reaction

butanal + CoA + NAD(P)+ ${\displaystyle \rightleftharpoons }$ butanoyl-CoA + NAD(P)H + H⁺

The 4 substrates of this enzyme are butanal, CoA, NAD⁺, and NADP⁺, whereas its 4 products are butanoyl-CoA, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is butanal:NAD(P)+ oxidoreductase (CoA-acylating). This enzyme participates in butanoate metabolism.

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