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Benzobarbital

Benzobarbital
Clinical data
Other namesBenzonal
ATC code
  • none
Identifiers
  • 1-benzoyl-5-ethyl-5-phenyl-1,3-diazinane-2,4,6-trione
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC19H16N2O4
Molar mass336.347 g·mol−1
3D model (JSmol)
  • CCC1(C(=O)NC(=O)N(C1=O)C(=O)C2=CC=CC=C2)C3=CC=CC=C3
  • InChI=1S/C19H16N2O4/c1-2-19(14-11-7-4-8-12-14)16(23)20-18(25)21(17(19)24)15(22)13-9-5-3-6-10-13/h3-12H,2H2,1H3,(H,20,23,25) checkY
  • Key:QMOWPJIFTHVQMB-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Benzobarbital (Benzonal) is a barbiturate derivative. It has anticonvulsant effects and has been used for the treatment of epilepsy.[1]

It has similar liver enzyme inducing effects to the closely related drug phenobarbital, which may be exploited in some clinical applications.[2][3]

References

  1. ^ Okudzhava VM, Chankvetadze BG (1989). "[Pharmacological characteristics of an anti-convulsive drug Benzonal and the evaluation of its therapeutic effectiveness (review of the literature)]". Zhurnal Nevropatologii I Psikhiatrii imeni S.S. Korsakova (in Russian). 89 (11): 136–45. PMID 2696306.
  2. ^ Nadzhimutdinov KN, Khakimov ZZ, Kabulov S (1992). "[The advantages of benzonal as an inducer of the liver mono-oxygenase enzyme system compared to phenobarbital]". Eksperimental'naia i Klinicheskaia Farmakologiia (in Russian). 55 (1): 68–71. PMID 1305441.
  3. ^ Novozheeva TP, Saratikov AS, Grishanova AI, Gutkina NI, Akhmedzhanov RR, Khatsenko OG, Kozlovskaia NE (February 1991). "[Benzonal--a phenobarbital-type of inducer of the mono-oxygenase system]". Biulleten' Eksperimental'noi Biologii I Meditsiny (in Russian). 111 (2): 163–5. OCLC 613807502. PMID 1854958.
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