The road is also known as "Autostrada dei Due Mari" ("Two seas motorway") because it connects Naples, on the Tyrrhenian coast, with Bari, on the Adriatic coast. It is a part of the E842 European route.
On the night of 28 July 2013, a serious traffic accident occurred on the A16 near Avellino when a coach carrying pilgrims fell off a flyover into a ravine. At least 39 people, including the driver, were killed and many others injured.[1]