Framed in the cardiac cycle, often historically accredited to the Wiggers diagram, arterial blood has just passed through the lungs and is ready to boost oxygen to sustain the peripheral organs. The essential difference between venous and arterial blood is the curve of the oxygen saturation of haemoglobin. The difference in the oxygen content of the blood between the arterial blood and the venous blood is known as the arteriovenous oxygen difference.[citation needed]