Highway 45 begins at Highway 96 in Hartford and runs north to meet Highway 252 on either side of Midland. Further north, the route has a 0.45 miles (0.72 km) concurrency with Highway 10 through downtown Hackett.[6] Slightly north of Highway 10, Highway 45 runs on the Hackett Creek Bridge and continues north to Bonanza. The route intersects Highway 253 and curves east to form a concurrency with US 71. The highway splits from US 71 to the north, entering Fort Smith, and intersects Highway 255 before terminating at I-540/US 71.[3]
The route begins at College Avenue and runs west as Lafayette Street through Fayetteville. Highway 45 runs through the Washington-Willow Historic District before a sharp left turn onto Mission Boulevard. The highway continues northeast until intersecting Highway 265 and exiting Fayetteville heading east. Passing the Son's Chapel and entering Goshen, the highway continues east through rural Washington County until entering Madison County shortly after a junction with Highway 303.[4] Highway 45 has a junction with Highway 295 before forming a concurrency with US 412B north through Hindsville. The route continues north, with US 412B terminating at a junction with US 412 and Highway 45 terminating at Highway 12 west of Clifty.[5]
^ abcdPlanning and Research Division (2010). "Arkansas Road Log Database". Arkansas State Highway and Transportation Department. Archived from the original(Database) on 23 June 2011. Retrieved June 9, 2011.
^ abGeneral Highway Map, Sebastian County, Arkansas(PDF) (Map). 1:62500. Cartography by Planning and Research Division. Arkansas State Highway and Transportation Department. May 10, 2010. Retrieved January 22, 2012.
^ abcGeneral Highway Map, Washington County, Arkansas(PDF) (Map). 1:62500. Cartography by Planning and Research Division. Arkansas State Highway and Transportation Department. December 22, 2011. Retrieved January 22, 2012.
^ abGeneral Highway Map, Madison County, Arkansas(PDF) (Map). 1:62500. Cartography by Planning and Research Division. Arkansas State Highway and Transportation Department. March 15, 2012. Retrieved January 22, 2012.