Archduchess Maria Luisa of Austria, Princess of Tuscany (full name: Maria Luisa Annunziata Anna Giovanna Giuseppa Antonietta Filomena Apollonia Tommasa) (31 October 1845 – 27 August 1917) was a Princess of Tuscany, and later Princess of Isenburg and Büdingen.
Maria Luisa was born in a time of peace and prosperity for the Grand Duchy of Tuscany, and she was raised in an loving family environment. However, she was first confronted with the dangers of her position at a young age, due to the Revolutions of 1848. In February 1849, the Grand Ducal family decided to go to Gaeta as a security measure. The Grand Duchess Maria Antonia traveled separately with her two younger children, Maria Luisa and Ludwig. The family remained in Gaeta for several months and was unable to return to Florence until 28 July 1849.
Later, Maria Luisa and her family were forced to flee Florence on 27 April 1859, with the outbreak of a revolution inspired by the war by France and Sardinia-Piedmont against Austria as part of the unification of Italy. The family took refuge in Austria. At the end of the war, her father Leopold II abdicated on 21 July and his son Ferdinand succeeded him as Grand Duke.
Prince Leopold Wolfgang Ernst (1866–1933), succeeded his father as Prince of Isenburg. In 1902 he wed Princess Olga of Saxe-Weimar-Eisenach (1869–1924), daughter of Prince Hermann of Saxe-Weimar-Eisenach, and had issue. He married secondly in 1924 Countess Marie von Dürckheim-Montmartin (1880–1937), without issue.
Generations are numbered by male-line descent from Frederick III, Holy Roman Emperor. Later generations are included although Austrian titles of nobility were abolished and outlawed in 1919.