Dereser was a Catholic representative of the Enlightenment, and promoted a rationalistic interpretation of the Bible. He had a marked tendency to take independent positions and defy authority—both secular and ecclesiastical—which involved him in numerous controversies and nearly cost him his life during the French Revolution.
As the Catholic Encyclopedia noted of him in 1913, "Dereser's combative character got him in trouble everywhere, and, though believing himself a good Catholic, he was imbued with a rationalistic, anti-Roman spirit", which made him "imbued with the shallow Rationalism of his time" and therefore "explaining away everything supernatural in Scripture and religion". This made all his writings "tainted" in the eyes of the Church authorities, though only one was placed on the Index Librorum Prohibitorum (see below) and that without the name of the author - testifying to the Church's appreciation of his talent, in spite of its dislike of his rationalism.
In 1791 he was sent to Strasbourg where he was a professor of Exegetical Theology and also filled the posts of preacher and of rector at the episcopal seminary. This embroiled him with the ongoing French Revolution. Dereser refused the Constitutional oath, making the clergy subordinate to the French civil authorities - an act which marked him out as a counter-revolutionary priest. During the Reign of Terror he was imprisoned and sentenced to death, but the capital punishment was commuted into one of deportation. It is not quite clear whether this was put into execution; but it is certain that with the fall of Robespierre he regained his liberty and returned with shattered health to the convent in Heidelberg (1796).
In 1799 he became professor of Semitic languages, exegesis and pastoral theology in Heidelberg. The Margrave of Baden withholding his consent to Dereser's acceptance of the office of coadjutor to the Bishop of Strasbourg, Dereser was transferred with the whole university to Freiburg (1807), but having given offence by a funeral sermon (1810) had to leave suddenly to Karlsruhe where he was a pastor, and then to Constance.
Thence he went to Lucerne where from 1811 to 1814 he was Rector of the Episcopal Seminary, but was expelled on account of his rationalistic teaching, which involved explaining away everything supernatural in Scripture and religion. He turned, on invitation, to Breslau as canon and professor of Dogmatic Theology (1815). There he spent the rest of his life.
^In its present incarnation, the University of Bonn is considered to have been founded in 1818; Dereser's book referred to the 1786 upgrading of its predecessor, the Academy of Bonn