Alois Alzheimer

Alois Alzheimer
Official Portrait of Alois Alzheimer
Born(1864-06-14)14 June 1864
Marktbreit, Kingdom of Bavaria
Died19 December 1915(1915-12-19) (aged 51)
Breslau, Kingdom of Prussia, German Empire
(present-day Wrocław, Poland)
Education
Known forFirst published case of "presenile dementia" (Alzheimer's disease)
Spouse
Cecilie Simonette Nathalie Geisenheimer
​
​
(m. 1894; died 1901)​
Children3
Medical career
ProfessionPsychiatrist, physician
Institutions
Sub-specialtiesNeuropathology
Signature

Alois Alzheimer (/ˈæltshaɪmər/ ALTS-hy-mər, US also /ˈɑːlts-, ˈɔːlts-/ AHLTS-, AWLTS-,[1][2] German: [ˈaːlɔɪs ˈʔaltshaɪmɐ]; 14 June 1864 – 19 December 1915) was a German psychiatrist, neuropathologist and colleague of Emil Kraepelin. He is credited with identifying the first published case of "presenile dementia", which Kraepelin later identified as Alzheimer's disease.[3]

Early life and education

Alzheimer's birthplace

Alzheimer was born in Marktbreit, Bavaria, on 14 June 1864, the son of Anna Johanna Barbara Sabina and Eduard Román Alzheimer.[4][5] His father served in the office of notary public in the family's hometown.[6] The family was devoutly Catholic.[7]

The Alzheimers moved to Aschaffenburg when Alois was still young in order to give their children an opportunity to attend the Royal Humanistic Gymnasium. After graduating with Abitur in 1883, Alzheimer studied medicine at University of Berlin, University of Tübingen, and University of Würzburg. In his final year at university, he was a member of a fencing fraternity, and even received a fine for disturbing the peace while out with his team.[8] In 1887, Alzheimer graduated from Würzburg as Doctor of Medicine.[8]

Career

In 1888, Alzheimer spent five months assisting mentally ill women before he took an office in the city mental asylum in Frankfurt, the Städtische Anstalt für Irre und Epileptische (Asylum for Lunatics and Epileptics). Emil Sioli [de], a noted psychiatrist, was the dean of the asylum. Another neurologist, Franz Nissl, began to work in the same asylum with Alzheimer. Together, they conducted research on the pathology of the nervous system, specifically the normal and pathological anatomy of the cerebral cortex.[8] Alzheimer was the co-founder and co-publisher of the journal Zeitschrift für die gesamte Neurologie und Psychiatrie, though he never wrote a book that he could call his own.[9]

While at the Frankfurt asylum, Alzheimer also met Emil Kraepelin, one of the best-known German psychiatrists of the time. Kraepelin became a mentor to Alzheimer, and the two worked very closely for the next several years. When Kraepelin moved to Munich to work at the Royal Psychiatric Hospital in 1903, he invited Alzheimer to join him.[8]

At the time, Kraepelin was doing clinical research on psychosis in senile patients; Alzheimer, on the other hand, was more interested in the lab work of senile illnesses.[10] They faced many challenges involving the politics of the psychiatric community. For example, formal and informal arrangements were made among psychiatrists at asylums and universities to receive cadavers.[10]

In 1904, Alzheimer completed his habilitation at Ludwig Maximilian University of Munich, where he was appointed as a professor in 1908. Afterward, he left Munich for the Silesian Friedrich Wilhelm University in Breslau in 1912, where he accepted a post as professor of psychiatry and director of the Neurologic and Psychiatric Institute. His health deteriorated shortly after his arrival so that he was hospitalized. He died three years later.[8]

Alzheimer is known for having a variety of medical interests including vascular diseases of the brain, early dementia, brain tumors, forensic psychiatry and epilepsy.[11]

Auguste Deter

In 1901, Alzheimer observed a patient at the Frankfurt asylum named Auguste Deter. The 51-year-old patient had strange behavioral symptoms, including a loss of short-term memory; she became his obsession over the coming years. Auguste Deter was a victim of the politics of the time in the psychiatric community;[10] the Frankfurt asylum was too expensive for her husband. Herr Deter made several requests to have his wife moved to a less expensive facility, but Alzheimer intervened in these requests. Auguste Deter, as she was known, remained at the Frankfurt asylum, where Alzheimer had made a deal to receive her records and brain upon her death, paying for the remainder of her stay in return.[12]

On 8 April 1906, Auguste Deter died, and Alzheimer had her medical records and brain brought to Munich where he was working in Kraepelin's laboratory. With two Italian physicians, he used the newly developed Bielschowsky stain to identify amyloid plaques and neurofibrillary tangles. These brain anomalies became identifiers of what is now known as Alzheimer's disease.[13]

First description of Alzheimer's dementia (1906)

On 3 November 1906 Alzheimer discussed his findings on the brain pathology and symptoms of presenile dementia publicly, at the Tübingen meeting of the Southwest German Psychiatrists.[8] The attendees at this lecture seemed uninterested in what he had to say. The lecturer that followed Alzheimer was to speak on the topic of "compulsive masturbation", which the audience of 88 individuals was so eagerly awaiting that they sent Alzheimer away without any questions or comments on his discovery of the pathology of a peculiar case of early-onset dementia.[8][14]

Following his presentation, Alzheimer published a short paper summarizing his presentation; in 1907 he wrote a longer paper detailing the disease and his findings.[8] It became known as Alzheimer's disease in 1910, when Kraepelin named it so in the chapter on "Presenile and Senile Dementia" in the 8th edition of his Handbook of Psychiatry. By 1911, his description of the disease was being used by European physicians to diagnose patients in the US.[15]

Additional case descriptions by Alzheimer and his colleagues continued in the following years, including older patients than the early-onset dementia of Auguste Deter.[16] Alzheimer eventually conceived "his" disease as mainly characterized clinically by a severe dementia with instrumental symptoms, and pathologically by extended neurofibrillary tangles.[17] He debated fiercely with Oskar Fischer, a german-speaking pathologist from Prague, who instead emphasized on the importance of neuritic plaques and of presbyophrenia[18] as the phenotype.[17] Finally, it must be highlighted that Fischer–Alzheimer's nosological considerations had less impact than Kraepelin's 1910 Textbook of Psychiatry, which distinguished between "Alzheimer's disease" and senile dementia, including presbyophrenia. This textbook had a strong influence on early 20th century research on senile dementia and played a significant role in the classification of dementia in the following decades.[17]

Personal life and death

Alzheimer in his later years just before his death (c. 1915)

In 1894, Alzheimer married Cecilie Simonette Nathalie Geisenheimer, with whom he had three children. She died in 1901.

Alzheimer's grave in Frankfurt

In August 1912, Alzheimer fell ill on the train on his way to the University of Breslau, where he had been appointed professor of psychiatry in July 1912. Most probably a streptococcal infection and subsequent rheumatic fever led to valvular heart disease, heart failure and kidney failure. He died of heart failure on 19 December 1915 at age 51, in Breslau, Silesia (present-day Wrocław, Poland). His body was buried four days later, next to Cecilie's at the Frankfurt Main Cemetery.[19]

Contemporaries

American Solomon Carter Fuller gave a report similar to that of Alzheimer at a lecture five months before Alzheimer.[8] Oskar Fischer was a fellow German psychiatrist, twelve years Alzheimer's junior, who reported twelve cases of senile dementia in 1907 around the time that Alzheimer published his short paper summarizing his presentation.[20]

Alzheimer and Fischer had different interpretations of the disease, but owing to Alzheimer's short life,[20] they never had the opportunity to meet and discuss their ideas.[19]

Critics and rediscovery

In the early 1990s, critics began to question Alzheimer's findings and form their own hypotheses based on Alzheimer's notes and papers. Amaducci and colleagues hypothesized that Auguste Deter had metachromatic leukodystrophy, a rare condition in which accumulations of fats affect the cells that produce myelin.[21] Claire O'Brien, meanwhile, hypothesized that Auguste Deter actually had a vascular dementing disease.[15]

See also

References

  1. ^ Jones, Daniel (2011). Roach, Peter; Setter, Jane; Esling, John (eds.). "Alzheimer's disease". Cambridge English Pronouncing Dictionary (18th ed.). Cambridge University Press. ISBN 978-0-521-15255-6.
  2. ^ "Alzheimer's disease". Random House Webster's Unabridged Dictionary.
  3. ^ Berrios, G. E. (1 November 1990). "Alzheimer's disease: A conceptual history". International Journal of Geriatric Psychiatry. 5 (6): 355–65. doi:10.1002/gps.930050603. ISSN 1099-1166. S2CID 145155424.
  4. ^ Zilka, N.; M. Novak (2006). "The tangled story of Alois Alzheimer" (PDF). Bratisl Lek Listy. 107 (9–10): 343–45. PMID 17262985. Archived (PDF) from the original on 9 October 2022. Retrieved 4 September 2012.
  5. ^ Maurer, Konrad; Maurer, Ulrike (2006). Alzheimer. La vida de un médico y la historia de una enfermedad. Ediciones Díaz de Santos. ISBN 978-84-7978-758-5.
  6. ^ "Alzheimer´s Birthplace" Archived 21 December 2008 at the Wayback Machine, marktbreit.de; accessed 14 July 2017.(in German)
  7. ^ Hippius, Hanns; Neundörfer, Gabriele (31 March 2003). "The discovery of Alzheimer's disease". Dialogues in Clinical Neuroscience. 5 (1): 101–108. doi:10.31887/DCNS.2003.5.1/hhippius. ISSN 1958-5969. PMC 3181715. PMID 22034141.
  8. ^ a b c d e f g h i Cipriani, Gabriele; Dolciotti, Cristina; Picchi, Lucia; Bonuccelli, Ubaldo (2011). "Alzheimer and his disease: a brief history". Neurological Sciences. 32 (2): 275–79. doi:10.1007/s10072-010-0454-7. ISSN 1590-1874. PMID 21153601. S2CID 8483005.
  9. ^ Hippius, Hanns; Neundörfer, Gabriele (March 2003). "The discovery of Alzheimer's disease". Dialogues in Clinical Neuroscience. 5 (1): 101–108. doi:10.31887/DCNS.2003.5.1/hhippius. ISSN 1294-8322. PMC 3181715. PMID 22034141.
  10. ^ a b c Engstrom, Eric J. (2007). "Researching Dementia in Imperial Germany: Alois Alzheimer and the Economies of Psychiatric Practice". Culture, Medicine and Psychiatry. 31 (3): 405–13. doi:10.1007/s11013-007-9060-4. ISSN 0165-005X. PMID 17914665. S2CID 46566744.
  11. ^ Lefroy, Richard B. (2000). "Sign In". American Journal of Alzheimer's Disease. 15 (4): 252–255. doi:10.1177/153331750001500404. S2CID 144484516.
  12. ^ Yang, Hyun Duk; et al. (December 2016). "History of Alzheimer's Disease". Dementia and Neurocognitive Disorders. 15 (4): 115–121. doi:10.12779/dnd.2016.15.4.115. PMC 6428020. PMID 30906352.
  13. ^ "Alois Alzheimer". Biography.com. 2 April 2014. Archived from the original on 23 March 2018. Retrieved 19 February 2019.
  14. ^ Benjamin, Sheldon; MacGillivray, Lindsey; Schildkrout, Barbara; Cohen-Oram, Alexis; Lauterbach, Margo D.; Levin, Leonard L. (24 August 2018). "Six Landmark Case Reports Essential for Neuropsychiatric Literacy". The Journal of Neuropsychiatry and Clinical Neurosciences. 30 (4): 279–290. doi:10.1176/appi.neuropsych.18020027. ISSN 0895-0172. PMID 30141725.
  15. ^ a b Maurer K.; Maurer U. (2003). Alzheimer: The Life of a Physician and Career of a Disease. New York: Columbia University Press. ISBN 978-0-231-11896-5.
  16. ^ Alzheimer, A. (1 December 1911). "über eigenartige Krankheitsfälle des späteren Alters". Zeitschrift für die gesamte Neurologie und Psychiatrie (in German). 4 (1): 356–385. doi:10.1007/BF02866241. ISSN 0303-4194.
  17. ^ a b c Villain, Nicolas; Michalon, Robin (November 2024). "What is Alzheimer's disease? An analysis of nosological perspectives from the 20th and 21st centuries". European Journal of Neurology. 31 (11). doi:10.1111/ene.16302. ISSN 1351-5101. PMC 11464395. PMID 38618742.
  18. ^ Berrios, G. E. (May 1986). "Presbyophrenia: the rise and fall of a concept". Psychological Medicine. 16 (2): 267–275. doi:10.1017/S0033291700009089. ISSN 1469-8978.
  19. ^ a b "Tuebingen: The Man Behind the Eponym". alzforum.org. Alzforum. 16 November 2006. Retrieved 25 January 2017.
  20. ^ a b Strobel, Gabrielle. "Prague: What say you, Alois – Should it be 'Alzheimer-Fischer' disease?". Journal of Alzheimer's Disease. 17 (3).
  21. ^ Graeber, M. B.; Mehraein, Parviz (1 December 1999). "Reanalysis of the first case of Alzheimer's disease". European Archives of Psychiatry and Clinical Neuroscience. 249 (3): S10–13. doi:10.1007/PL00014167. ISSN 0940-1334. PMID 10654094. S2CID 9063617.
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