7-carboxy-7-deazaguanine synthase

7-carboxy-7-deazaguanine synthase
Identifiers
EC no.4.3.99.3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
PubMedarticles
NCBIproteins

7-Carboxy-7-deazaguanine synthase (EC 4.3.99.3, 7-carboxy-7-carbaguanine synthase, queE (gene)) is an enzyme with systematic name 6-carboxy-5,6,7,8-tetrahydropterin ammonia-lyase.[1] This enzyme catalyses the following chemical reaction

6-carboxy-5,6,7,8-tetrahydropterin 7-carboxy-7-carbaguanine + NH3

The enzyme is a member of the superfamily of S-adenosyl-L-methionine-dependent radical enzymes.

References

  1. ^ McCarty RM, Somogyi A, Lin G, Jacobsen NE, Bandarian V (May 2009). "The deazapurine biosynthetic pathway revealed: in vitro enzymatic synthesis of PreQ0 from guanosine 5′-triphosphate in four steps". Biochemistry. 48 (18): 3847–52. doi:10.1021/bi900400e. PMC 2693876. PMID 19354300.