Front office

• Chairman/owner/president – Dean Spanos
• Vice chairman – Michael Spanos
• Executive vice president/COO/CFO – Jeanne Bonk
• CEO/president of business operations – A. G. Spanos
• General manager – Joe Hortiz
• Assistant general manager – Chad Alexander
• President of football operations – John Spanos
• Executive vice president of football administration/player finance – Ed McGuire
• Director of player personnel strategy – Corey Krawiec
• Director of pro scouting – Dennis Abraham
• Senior director of pro personnel – Louis Clark
• Senior director of college scouting – Kevin Kelly
• Assistant director of pro scouting – Tyler Lyon

Head coaches

• Head coach – Jim Harbaugh

Offensive coaches

• Offensive coordinator – Greg Roman
• Passing game coordinator – Marcus Brady
• Quarterbacks – Shane Day
• Running backs – Kiel McDonald
• Wide receivers – Sanjay Lal
• Tight ends/run game coordinator – Andy Bischoff
• Offensive line – Mike Devlin
• Assistant offensive line – Nick Hardwick
• Senior offensive assistant – Marc Trestman
• Offensive assistant – Phil Serchia
• Offensive assistant/quarterbacks – Jonathan Goodwin
• Offensive quality control/wide receivers – Jeff Carpenter

Defensive coaches

• Defensive coordinator – Jesse Minter
• Defensive line – Mike Elston
• Assistant defensive line – Will Tukuafu
• Linebackers – NaVorro Bowman
• Defensive backs – Steve Clinkscale
• Safeties – Chris O'Leary
• Senior defensive analyst – Rick Minter
• Defensive assistant – Dylan Roney
• Defensive assistant – Mike Hiestand
• Defensive quality control – Robert Muschamp

Special teams

• Special teams coordinator – Ryan Ficken
• Assistant special teams – Chris Gould

Strength and conditioning

• Executive director of player performance – Ben Herbert
• Head of strength and conditioning – Jonathan Brooks
• Head of strength and conditioning – Devin Woodhouse
• Director of performance analytics – Ben Rabe
• Performance analyst – Lincoln Dewolf

→ Coaching staff
→ Front office
→ More NFL staffs

•  8 Taylor Heinicke

• 10 Justin Herbert

•  2 Easton Stick

Running backs (RB)

• 27 J. K. Dobbins

•  4 Gus Edwards

• 28 Hassan Haskins

• 44 Scott Matlock FB

• 30 Kimani Vidal

Wide receivers (WR)

•  9 D. J. Chark

• 12 Derius Davis

• 87 Simi Fehoko

•  1 Quentin Johnston

• 15 Ladd McConkey

•  5 Josh Palmer

• 89 Jalen Reagor

• 82 Brenden Rice

Tight ends (TE)

• 81 Will Dissly

• 42 Tucker Fisk

• 88 Hayden Hurst

• 84 Stone Smartt

• 76 Joe Alt RT

• 75 Bradley Bozeman C

• 64 Brenden Jaimes C

• 77 Zion Johnson LG

• 74 Tyler McLellan RT

• 62 Sam Mustipher C

• 79 Trey Pipkins RG

• 68 Jamaree Salyer G

• 73 Foster Sarell LT

• 70 Rashawn Slater LT

• 60 Bucky Williams C

Defensive linemen (DL)

• 92 Justin Eboigbe DE

• 95 Poona Ford NT

• 56 Morgan Fox DE

• 93 Otito Ogbonnia NT

• 90 Teair Tart DT

• 97 Joey Bosa OLB

• 53 Chris Collins OLB

• 25 Junior Colson ILB

• 48 Bud Dupree OLB

• 43 Troy Dye ILB

•  0 Daiyan Henley ILB

• 52 Khalil Mack OLB

• 31 Nick Niemann ILB

•  6 Denzel Perryman ILB

• 58 Shaq Quarterman ILB

• 94 Chris Rumph II OLB

• 45 Tuli Tuipulotu OLB

Defensive backs (DB)

• 41 Eli Apple CB

•  7 Kristian Fulton CB

• 32 Alohi Gilman FS

• 20 Cam Hart CB

•  3 Derwin James SS

• 23 Tony Jefferson FS

• 33 Deane Leonard CB

• 24 Marcus Maye FS

• 22 Elijah Molden SS

• 26 Asante Samuel Jr. CB

• 29 Tarheeb Still CB

• 36 Ja'Sir Taylor CB

Special teams

• 11 Cameron Dicker K

• 47 Josh Harris LS

• 16 J. K. Scott P

Reserve

• 61 Karsen Barnhart G (Futures)

• 46 McCallan Castles TE (Futures)

• 82 Dez Fitzpatrick WR (Futures)

• 91 Christopher Hinton NT (Futures)

• 51 Jeremiah Jean-Baptiste ILB (Futures)

• 39 Jaylen Johnson WR (Futures)

• 57 Tre'Mon Morris-Brash OLB (Futures)

• 50 Caleb Murphy OLB (Futures)

• 34 Jaret Patterson RB (Futures)

• 40 Kendall Williamson S (Futures)