16 July – Police seize over four tons of cocaine worth $240 million at a river port in Asunción, the largest cocaine seizure in the country's history.[1]
6 August – The United States imposes sanctions on the cigarette manufacturer Tabacalera del Este and four other firms for supporting the illicit enrichment of former president Horacio Cartes.[2]
8 August – Paraguay orders the expulsion of US ambassador Marc Ostfield in protest over the imposition of sanctions against Tabacalera del Este on 6 August.[3]
19 August – National Deputy Lalo Gomes is killed in his residence in Pedro Juan Caballero during a shootout with drug enforcement agents searching for his son, who later surrenders.[4]
5 December – Paraguay expels a Chinese diplomat who called for legislators to recognize Beijing in a surprise visit to Congress.[5]
12 December – Paraguay moves its embassy in Israel to Jerusalem for the second time since relocating it to Tel Aviv in 2018.[6]
