The game featured Ohio State from the Big Ten Conference and Missouri from the Southeastern Conference (SEC). This was the 13th all-time meeting between the Buckeyes and Tigers, with Ohio State leading the series 10–1–1.[5] Their most recent prior meeting was September 19, 1998, a 35–14 Buckeyes win at home. Missouri's lone win came during the 1976 season.
Missouri started the season 5–0, including a victory over No. 15 Kansas State on a game-winning 61-yard field goal by Harrison Mevis. The Tigers were subsequently ranked in the AP poll. However, they were defeated at home by LSU, 49–39, and three weeks later lost on the road to top-ranked Georgia, 30–21, ending their SEC title hopes. Missouri followed their loss to Georgia with a strong 36–7 win over Tennessee, and ended their season on a three-game winning streak and a 10–2 record (6–2 in SEC). The Tigers entered the bowl ranked ninth in all major polls.
Ohio State entered the year looking to improve upon their 2022 season, when they received a College Football Playoff berth but lost to Georgia in the 2022 Peach Bowl semifinal. The Buckeyes earned marquee wins over Notre Dame and Penn State by margins of 17–14 and 20–12, respectively. However, in a top-three rivalry clash against Michigan in their final game of the regular season, the Buckeyes lost 30–24 in Ann Arbor, leaving them with an 11–1 record (8–1 in Big Ten) and out of playoff contention. The Buckeyes entered the bowl ranked seventh in all major polls.
There was a Cotton Bowl Classic in January and December in 1966, 2015, 2017, 2023, 2025.
The 2015 (December), 2018, 2021, and 2025 (January) editions were College Football Playoff semifinals.