The men's 50m butterfly events at the 2022 World Para Swimming Championships were held at the Penteada Olympic Swimming Complex in Madeira between 12–18 June.

Event	Gold	Silver	Bronze
S5	Samuel da Silva de Oliveira  Brazil	Kaede Hinata  Japan	Siyazbek Daliyev  Kazakhstan
S6	Laurent Chardard  France	Nelson Crispín  Colombia	David Sanchez Sierra  Spain
S7	Andrii Trusov  Ukraine	Carlos Serrano Zárate  Colombia	Iñaki Basiloff  Argentina

Final

Eight swimmers from seven nations took part.^[1]

Rank	Athlete	Nation	Result	Notes
	Samuel da Silva de Oliveira	Brazil	33.23
	Kaede Hinata	Japan	35.06
	Siyazbek Daliyev	Kazakhstan	36.32
4	Abbas Karimi	United States	36.87
5	Alexandros-Stylianos Lergios	Greece	38.72
6	Tiago de Oliveira Ferreira	Brazil	39.19
7	Miguel Ángel Rincón	Colombia	41.63
	Koral Berkin Kutlu	Turkey	DSQ