Singles
2022 San Marino Open
Final
Champion	Pavel Kotov
Runner-up	Matteo Arnaldi
Score	7–6(7–5), 6–4
Events
Singles Doubles
← 2021 · San Marino Open · 2023 →

Holger Rune was the defending champion^[1] but chose not to defend his title.

Pavel Kotov won the title after defeating Matteo Arnaldi 7–6^(7–5), 6–4 in the final.

	Semifinals							Final
	Alt	Filip Cristian Jianu	1	5
	8	Matteo Arnaldi	6	7
								8	Matteo Arnaldi	65	4
								2	Pavel Kotov	77	6
	5	Marco Cecchinato	6	5	1
	2	Pavel Kotov	3	7	6

	First round							Second round							Quarterfinals							Semifinals
	1	C Taberner	6	2	6
		O Roca Batalla	4	6	2			1	C Taberner	4	3
	Alt	FC Jianu	77	6				Alt	FC Jianu	6	6
	WC	E Gulbis	64	0											Alt	FC Jianu	6	6
		R Haase	77	6												N Sánchez Izquierdo	2	4
		O Virtanen	63	3					R Haase	6	1	3
		N Sánchez Izquierdo	3	6	6				N Sánchez Izquierdo	2	6	6
	6	A Müller	6	3	0																	Alt	FC Jianu	1	5
	4/WC	F Cobolli	65	4																		8	M Arnaldi	6	7
		F Marozsán	77	6					F Marozsán	6	6
		J Sels	2	3					M Gigante	2	2
		M Gigante	6	6												F Marozsán	4	2
	Alt	I Gakhov	2	64											8	M Arnaldi	6	6
	Q	L Neumayer	6	77				Q	L Neumayer	3	4
		F Gaio	2	0				8	M Arnaldi	6	6
	8	M Arnaldi	6	6

	First round							Second round							Quarterfinals							Semifinals
	5	M Cecchinato	6	6
	WC	M Bellucci	2	1				5	M Cecchinato	63	78	6
		N Fatić	3	2				Q	F Forti	77	66	2
	Q	F Forti	6	6											5	M Cecchinato	77	6
		J de Jong	6	6											Q	V Vacherot	63	1
		M Trungelliti	3	4					J de Jong	2	3
	Q	V Vacherot	2	77	6			Q	V Vacherot	6	6
	3	G Zeppieri	6	62	1																	5	M Cecchinato	6	5	1
	7	N Serdarušić	60	6	3																	2	P Kotov	3	7	6
		L Giustino	77	4	6				L Giustino	2	5
		T Skatov	3	1				Q	A Weis	6	7
	Q	Alexander Weis	6	6											Q	A Weis	5	0
	Alt	M Janvier	6	3	7										2	P Kotov	7	6
	Q	O Prihodko	1	6	5			Alt	M Janvier	4	3
	Q	V Durasovic	1	1				2	P Kotov	6	6
	2	P Kotov	6	6

• Main draw
• Qualifying draw