The men's doubles of the 2022 I.ČLTK Prague Open tournament took place on clay in Prague, Czech Republic.
Marc Polmans and Sergiy Stakhovsky were the winners of the last edition[1] but did not defend their title. Polmans chose not to participate, while Stakhovsky retired at the beginning of 2022.[2]
Nuno Borges and Francisco Cabral won the title after defeating Andrew Paulson and Adam Pavlásek 6–4, 6–7(3–7), [10–5] in the final.