Starting from the round of 16, the teams are seeded according to their results in the group stage, with the Copa Sudamericana group winners (Pot 1) seeded 1–8, and the Copa Libertadores group third-placed teams (Pot 2) seeded 9–16.
In the round of 16, quarter-finals and semi-finals, each tie is played on a home-and-away two-legged basis, with the higher-seeded team hosting the second leg (Regulations Article 2.2.3). If tied on aggregate, extra time will not be played, and a penalty shoot-out will be used to determine the winners (Regulations Article 2.4.4).
The final is played as a single match at a venue pre-selected by CONMEBOL, with the higher-seeded team designated as the "home" team for administrative purposes (Regulations Article 2.2.6). If tied after regulation, 30 minutes of extra time will be played. If still tied after extra time, a penalty shoot-out will be used to determine the winners (Regulations Article 2.4.5).
Draw
The draw for the round of 16 was held on 27 May 2022, 12:00 PYT (UTC−4) at the CONMEBOL Convention Center in Luque, Paraguay.[4][5] For the round of 16, the 16 teams were drawn into eight ties (A–H) between a Copa Sudamericana group winner (Pot 1) and a Copa Libertadores group third-placed team (Pot 2), with the group winners hosting the second leg. Teams from the same association or the same group could be drawn into the same tie (Regulations Article 2.2.3.2).[2]
Bracket
The bracket starting from the round of 16 is determined as follows:
Round
Matchups
Round of 16
(Group winners host second leg, matchups decided by draw)
Match A
Match B
Match C
Match D
Match E
Match F
Match G
Match H
Quarter-finals
(Higher-seeded team host second leg)
Match S1: Winner A vs. Winner H
Match S2: Winner B vs. Winner G
Match S3: Winner C vs. Winner F
Match S4: Winner D vs. Winner E
Semi-finals
(Higher-seeded team host second leg)
Match F1: Winner S1 vs. Winner S4
Match F2: Winner S2 vs. Winner S3
Finals
(Higher-seeded team designated as "home" team)
Winner F1 vs. Winner F2
The bracket was decided based on the round of 16 draw, which was held on 27 May 2022.
^Santos played their home match at their regular stadium Estádio Urbano Caldeira, Santos instead of the originally scheduled Estádio do Morumbi, São Paulo.[8]
^Universidad Católica played their home match against São Paulo at their regular stadium Estadio San Carlos de Apoquindo, Santiago, instead of the originally scheduled Estadio Nacional Julio Martínez Prádanos, Santiago.[11]
^Olimpia played their home match at Estadio Defensores del Chaco, Asunción, instead of their regular stadium Estadio Manuel Ferreira, Asunción.
^ abcAtlético Goianiense played their home matches at Estádio Serra Dourada, Goiânia, instead of their regular stadium Estádio Antônio Accioly, Goiânia which did not meet CONMEBOL requirements.
^Independiente del Valle played their home match against Lanús at Estadio Olímpico Atahualpa, Quito, instead of the originally scheduled Estadio Rodrigo Paz Delgado, Quito.[11]
^ abIndependiente del Valle played their home matches at Estadio Rodrigo Paz Delgado, Quito, instead of their regular stadium Estadio Banco Guayaquil, Quito which did not meet CONMEBOL requirements.
^ abBoth Independiente del Valle v Melgar matches, originally scheduled at 17:15 local time, were re-scheduled to 19:30 local time.[31]
