The 2021–22 season was the 102nd season in the existence of U.S. Sassuolo Calcio and the club's ninth consecutive season in the top flight of Italian football. In addition to the domestic league, Sassuolo participated in this season's edition of the Coppa Italia.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
Source: Serie A Rules for classification: 1) Points; 2) Head-to-head points; 3) Head-to-head goal difference; 4) Goal difference; 5) Goals scored; 6) Draw. (Note: Head-to-head record is used only after all the matches between the teams in question have been played) Notes:
^ abTorino finished ahead of Sassuolo on head-to-head points: Sassuolo 0–1 Torino, Torino 1–1 Sassuolo.