The 2021–22 season was Pisa S.C.'s third consecutive season in second division of the Italian football league, the Serie B, and the 113th as a football club.
Players
First-team squad
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.