Singles
2021 Quito Challenger
Final
Champion	Facundo Mena
Runner-up	Gonzalo Lama
Score	6–4, 6–4
Events
Singles Doubles
← 2017 · Quito Challenger · 2022 →

Nicolás Jarry was the defending champion^[1] but chose not to defend his title.

Facundo Mena won the title after defeating Gonzalo Lama 6–4, 6–4 in the final.

	Semifinals							Final
		Pol Martín Tiffon	611	4
		Gonzalo Lama	713	6
									Gonzalo Lama	4	4
								6	Facundo Mena	6	6
	6	Facundo Mena	6	4	6
	Q	Alexis Gautier	2	6	2

	First round							Second round							Quarterfinals							Semifinals
	1	A Martin	66	5
		Pol Martín Tiffon	78	7					P Martín Tiffon	4	77	6
		A González	6	77					A González	6	64	3
	Q	L Castelnuovo	2	64												P Martín Tiffon	3	6	6
		Eduard Esteve Lobato	6	6											5	JP Ficovich	6	3	4
		G Oliveira	2	3					E Esteve Lobato	6	65	4
		L Catarina	2	4				5	JP Ficovich	2	77	6
	5	JP Ficovich	6	6																			P Martín Tiffon	611	4
	3	M Vilella Martínez	6	65	6																		G Lama	713	6
	Q	Christian Langmo	3	77	2			3	M Vilella Martínez	6	64	3
		G Lama	7	4	6				G Lama	3	77	6
	WC	A Guillén Meza	5	6	2											G Lama	77	77
		C Gómez-Herrera	2	4											7	TA Tirante	65	64
		A Menéndez Maceiras	6	6					A Menéndez Maceiras	5	2
		P Kypson	79	1	3			7	TA Tirante	7	6
	7	TA Tirante	67	6	6

	First round							Second round							Quarterfinals							Semifinals
	6	F Mena	78	7
	Q	A Gómez	66	5				6	F Mena	6	6
		Matías Zukas	77	5	64				C Rodríguez	2	4
		C Rodríguez	64	7	77										6	F Mena	6	6
		GA Olivieri	3	6	7											GA Olivieri	4	0
		O Roca Batalla	6	3	5				GA Olivieri	6	6
		G Villanueva	4	4				4	R Olivo	2	2
	4	R Olivo	6	6																		6	F Mena	6	4	6
	8	R Quiroz	6	7																		Q	A Gautier	2	6	2
		D Hidalgo	4	5				8	R Quiroz	6	2	3
		Matthieu Perchicot	6	6					M Perchicot	2	6	6
	WC	AC March	4	0												M Perchicot	4	3
		J Nikles	0	4											Q	A Gautier	6	6
	Q	Alexis Gautier	6	6				Q	A Gautier	7	77
	WC	Gian Carlos Rodríguez	1	2				2	E Gómez	5	62
	2	E Gómez	6	6

• Main draw
• Qualifying draw