Wheelchair women's singles
2021 Australian Open
Final
Champion	Diede de Groot
Runner-up	Yui Kamiji
Score	6–3, 6–7(4–7), 7–6(10–4)
Details
Draw	8
Seeds	2
Events
Singles men women boys girls Doubles men women mixed boys girls WC Singles men women quad WC Doubles men women quad Legends men women mixed
← 2020 · Australian Open · 2022 →

Diede de Groot defeated the defending champion Yui Kamiji in the final, 6–3, 6–7^(4–7), 7–6^(10–4) to win the women's singles wheelchair tennis title at the 2021 Australian Open. It was the first step in an eventual Super Slam for de Groot.

	Quarterfinals							Semifinals							Final
	1	Diede de Groot	6	3	6
		Aniek van Koot	0	6	4
								1	Diede de Groot	6	6
									Momoko Ohtani	2	4
		Momoko Ohtani	6	6
		Lucy Shuker	2	2
															1	Diede de Groot	6	64	710
															2	Yui Kamiji	3	77	64
		Angélica Bernal	1	2
		Kgothatso Montjane	6	6
									Kgothatso Montjane	1	7	0
								2	Yui Kamiji	6	5	6
		Macarena Cabrillana	0	1
	2	Yui Kamiji	6	6

• Drawsheet on ausopen.com