The two newly promoted teams, EAD/PK 12 and Arhiba FC, were both relegated. Arhiba lost every game while EAD / PK 12 finished 9th on goal difference after a 0–1 loss to FC Dikhil in their final match.
Source: RSSSF Rules for classification: 1) points; 2) goal difference; 3) number of goals scored; 4) head-to-head points; 5) head-to-head goal difference; 6) head-to-head goals scored; 7) draw. Notes:
^Since the winners of the 2021–22 Djibouti Cup, Arta/Solar7, qualified for the Champions League group stage by league position, the spot given to the Djibouti Cup winners (CAF Confederation Cup preliminary round) was passed down to the runners up.